低浓度 EGCG 对大肠癌细胞奥沙利铂敏感性的二分作用

IF 0.8 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zhiyong Wang, Min Wang, Jiahao Huang, Mao Lin, Pei Wei
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引用次数: 0

摘要

尽管表没食子儿茶素-3-棓酸盐(EGCG)在高浓度下可增强化疗药物的疗效,但其临床应用却因超过可能的浓度阈值而受到阻碍。本研究提出了在化疗中使用低浓度 EGCG 的两分法。在与奥沙利铂(OXA)联合治疗的第一周期中,低浓度 EGCG 可拮抗 OXA 对结直肠癌细胞的细胞毒性作用。然而,当随后服用 OXA 时,CRC 细胞的敏感性明显增加。虽然低浓度的EGCG能抵消OXA的作用,但它能减少肿瘤细胞分泌由OXA诱导的血管内皮生长因子,从而导致肿瘤细胞对第二轮OXA治疗的敏感性增加。因此,低浓度EGCG有望成为调节CRC化疗敏感性的有效辅助药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells

Dichotomic Role of Low-Concentration EGCG in the Oxaliplatin Sensitivity of Colorectal Cancer Cells

Although epigallocatechin-3-gallate (EGCG) can potentiate chemotherapeutic drugs at high concentrations, its clinical translation is hampered by exceeding possible concentration thresholds. This study proposes a dichotomous use of low-concentration EGCG in chemotherapy. During the first cycle of combined treatment with oxaliplatin (OXA), low-concentration EGCG antagonized the cytotoxic effect of OXA on colorectal cancer (CRC) cells. However, when OXA was subsequently administered, the sensitivity of CRC cells markedly increased. Although low-concentration EGCG counteracted OXA, it reduced the OXA-induced secretion of vascular endothelial growth factor by tumor cells, thereby contributing to the increase in the sensitivity of tumor cells to the second round of OXA treatment. Therefore, low-concentration EGCG showed potential as a viable adjunct to modulate chemosensitivity in CRC.

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来源期刊
Doklady Biochemistry and Biophysics
Doklady Biochemistry and Biophysics 生物-生化与分子生物学
CiteScore
1.60
自引率
12.50%
发文量
68
审稿时长
6-12 weeks
期刊介绍: Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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