慢性淋巴细胞白血病患者的疫苗接种

IF 5 3区医学 Q1 HEMATOLOGY

Seminars in hematology Pub Date : 2024-04-01 DOI:10.1053/j.seminhematol.2024.01.003

Elizabeth R. Francis , Jennifer Vu , Catherine Ostos Perez , Clare Sun

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引用次数: 0

摘要

慢性淋巴细胞白血病（CLL）的特点是免疫功能失调，导致感染易感性增加，发病率和死亡率升高。减轻感染相关并发症的关键策略是对常见病原体进行免疫接种。然而，CLL 患者的免疫功能低下状况给疫苗接种引起足够的体液和细胞免疫反应带来了挑战。大多数慢性淋巴细胞白血病的定向治疗会不成比例地损害体液免疫。疫苗反应性还取决于免疫接种引发的免疫反应的阶段和类型。在本综述中，我们将讨论免疫功能障碍、疫苗反应性以及优化 CLL 患者疫苗反应的注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vaccinations in patients with chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is characterized by immune dysfunction resulting in heightened susceptibility to infections and elevated rates of morbidity and mortality. A key strategy to mitigate infection-related complications has been immunization against common pathogens. However, the immunocompromised status of CLL patients poses challenges in eliciting an adequate humoral and cellular immune response to vaccination. Most CLL-directed therapy disproportionately impairs humoral immunity. Vaccine responsiveness also depends on the phase and type of immune response triggered by immunization. In this review, we discuss the immune dysfunction, vaccine responsiveness, and considerations for optimizing vaccine response in patients with CLL.

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来源期刊

Seminars in hematology 医学-血液学

CiteScore

6.20

自引率

2.80%

发文量

审稿时长

35 days

期刊介绍： Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.