棉酚对人红细胞Na+、K+跨膜通量的影响。

Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao Pub Date : 1989-01-01

Y Jin, H C Chen, W H Wo, M Z Yang, S P Xue

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引用次数: 0

摘要

研究了棉酚乙酸(一种男性避孕药)对人红细胞钠、钾跨膜通量的影响，并与瓦巴因(一种Na+-K+- atp酶抑制剂)和呋塞米(一种Na+， K+共转运抑制剂)的影响进行了比较。发现棉酚可能是人红细胞向外(Na+， K+)共转运的抑制剂，但对(Na+， K+)- atp酶无显著影响。该结果为阐明棉酚引起低钾血症的机制提供了新的依据。

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Effects of gossypol on Na+, K+ transmembrane fluxes in human red cells.

The effects of gossypol-acetic acid (a male contraceptive) on transmembrane fluxes of sodium and potassium in human red cells were studied, in comparison with the effects of ouabain (an inhibitor of Na+-K+-ATPase) and furosemide (an inhibitor of Na+, K+ cotransport). It was found that gossypol may be an inhibitor of outward (Na+, K+) cotransport in human red cells but has no significant effect on (Na+, K+)-ATPase. The results provide new evidence for elucidating the mechanism of hypokalemia caused by gossypol.

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Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao

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