他汀类药物剂量与因缺血性心肌病而使用植入式心律转复除颤器进行一级预防的患者恶性室性心律失常之间的关系

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Ö. Karaaslan, Atik Aksoy, Murat Oğuz Özilhan, Ü. Güray, M. Selçuk, H. Selçuk, O. Maden
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引用次数: 0

摘要

背景:恶性室性心律失常是缺血性心脏病的常见死因。植入式心律转复除颤器(ICD)在降低与室性心律失常相关的死亡率方面具有显著疗效。他汀类药物具有稳定动脉粥样硬化和缺血负担的潜力,因此可能具有间接抗心律失常的作用。本研究评估了因缺血性心肌病而使用一级预防 ICD 的患者体内他汀类药物水平与心律失常事件之间的关系。研究方法本研究是在一个中心进行的回顾性观察研究,研究对象是在心脏病学门诊就诊并接受 ICD 一级预防的连续患者。根据他汀类药物的使用情况将研究对象分为两组。研究结果该研究包括 80 名被诊断为缺血性心肌病并接受 ICD 一级预防植入术的患者。第一组包括 24 名服用低剂量他汀类药物的患者,第二组包括 56 名服用高剂量他汀类药物的患者。单变量和多变量分析表明,左心室射血分数和使用低剂量他汀类药物是心律失常事件的独立预测因素。结论研究队列具有相似的临床和实验室特征,这表明他汀类药物的剂量与同质患者群体中的恶性心律失常事件有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The association between statin dosage and malignant ventricular arrhythmias in patients with primary prevention implantable cardioverter-defibrillators for ischemic cardiomyopathy
Background: Malignant ventricular arrhythmias are a common cause of death in ischemic heart diseases. Implantable cardioverter-defibrillators (ICDs) demonstrate significant efficacy in reducing mortality linked to ventricular arrhythmias. Statins exhibit the potential to stabilize the atherosclerotic and ischemic burden, thereby potentially manifesting indirect anti-arrhythmic effects. This study evaluated the relationship between statin levels and arrhythmic events in patients with primary prevention ICDs for ischemic cardiomyopathy. Methods: This study was conducted as a retrospective observational study at a single center, involving consecutive patients who were admitted to the cardiology outpatient clinic and underwent primary prevention ICD. The study population was stratified into two groups based on statin usage. Results: This study included a cohort of 80 patients diagnosed with ischemic cardiomyopathy who underwent primary prevention implantation of ICDs. Group 1 consisted of 24 patients who were prescribed low-dose statins, whereas Group 2 consisted of 56 patients who were prescribed high-dose statins. Univariate and multivariate analyses showed that left ventricular ejection fraction and use of low-dose statins were independent predictors of arrhythmic events. Conclusion: The study cohort exhibited comparable clinical and laboratory characteristics, suggesting that statin dosage is associated with malignant arrhythmic events in a homogeneous patient population.
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来源期刊
Research in Cardiovascular Medicine
Research in Cardiovascular Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-
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审稿时长
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