肥胖症手术治疗对非酒精性脂肪肝病程的影响

Q3 Medicine
A. S. Pushkareva, N. V. Mazurina, K. Komshilova, E. Ershova
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)是一种肝脏疾病,其特征是肝细胞内脂肪内含物堆积,包括从脂肪变性到肝硬化的一系列肝脏病变。鉴于肥胖及相关非酒精性脂肪肝的发病率越来越高,人们正在寻找最佳的治疗方法。作者分析了已发表的有关减肥手术对肝脏形态变化影响的临床研究。作者在Pubmed数据库和еLibrary.ru中以 "非酒精性脂肪肝"、"肥胖"、"减肥手术 "为关键词搜索了1990年至2022年期间的文献。研究既考虑了肥胖症手术治疗的积极作用,即减少肝脏脂肪变性和脂肪性肝炎,也考虑了手术后患者肝硬化加重的不利影响。尽管减肥手术对与肥胖相关的代谢综合征的组成部分有明显的疗效,但对其对非酒精性脂肪肝的疗效仍没有明确的看法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of surgical treatment of obesity on the course of nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a liver disease with a characteristic accumulation of fatty inclusions in hepatocytes and includes a spectrum of liver lesions from steatosis to cirrhosis. In view of the increasing incidence of obesity and associated NAFLD, a search is underway for optimal treatments. The authors analyzed published clinical studies on the effect of bariatric surgery on morphological changes in the liver. The literature was searched for the keywords «non-alcoholic fatty liver disease», «obesity», «bariatric surgery» in Pubmed databases and еLibrary.ru for the period from 1990 to 2022 . Both the positive effects of surgical treatment of obesity in the form of a decrease in steatosis, steatohepatitis of the liver, and adverse effects in the form of aggravation of cirrhosis in patients after surgery are considered. Despite the obvious effectiveness of bariatric surgery in relation to the components of the metabolic syndrome associated with obesity, there is still no unambiguous opinion about their effectiveness in relation to NAFLD.
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来源期刊
Obesity and Metabolism
Obesity and Metabolism Medicine-Internal Medicine
CiteScore
1.30
自引率
0.00%
发文量
39
期刊介绍: Journal "Obesity and Metabolism" is a multidisciplinary forum for clinical and applied research in the field of biochemistry, physiology, pathophysiology, genetics, nutrition, as well as molecular, metabolic, psychological and epidemiological aspects of obesity and metabolism. The main subject "Metabolism" reviewed in the journal, includes fat, carbohydrate, protein, bone, fluid and electrolyte and other types of metabolism in the spectrum of pathology of the endocrine system. The priority direction of Journal "Obesity and Metabolism" is publishing modern high-quality original research on the effectiveness of new and existing treatments in any aspect of metabolic and endocrine diseases. Pre-clinical pharmacology, pharmacokinetics studies, meta-analyzes, addressed to drug safety and tolerance are also welcome for publication in the journal "Obesity and metabolism." Journal "Obesity and Metabolism" announces review articles that are balanced, clear and offer the reader a modern and critical analysis of the literature on the subject of the magazine. Case reports, and lecture materials are also published for highlighting for practitioners new approaches to diagnosis and treatment of patients with metabolic disorders and obesity.
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