Nguyen Thi Hai Ha, Nguyen Van Tuyen, N. Son, L. Anh, Nguyen Thi Thuy Linh, Pham Minh Quan, Le Thi Hai Yen, Nguyen Van Du
{"title":"alocasia odora K. Koch 根茎的植物化学研究和抗菌活性","authors":"Nguyen Thi Hai Ha, Nguyen Van Tuyen, N. Son, L. Anh, Nguyen Thi Thuy Linh, Pham Minh Quan, Le Thi Hai Yen, Nguyen Van Du","doi":"10.15625/2525-2518/17303","DOIUrl":null,"url":null,"abstract":"Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":"34 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch\",\"authors\":\"Nguyen Thi Hai Ha, Nguyen Van Tuyen, N. Son, L. Anh, Nguyen Thi Thuy Linh, Pham Minh Quan, Le Thi Hai Yen, Nguyen Van Du\",\"doi\":\"10.15625/2525-2518/17303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.\",\"PeriodicalId\":23553,\"journal\":{\"name\":\"Vietnam Journal of Science and Technology\",\"volume\":\"34 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vietnam Journal of Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15625/2525-2518/17303\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vietnam Journal of Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15625/2525-2518/17303","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch
Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.