75gms OGTT 检测 GDM 的有效性,以 100gms OGTT 为黄金标准

Shazia Mehreen, Muhammad Usman, Kashif Rauf, Saima Naz, Muhammad Abdul Rab Faisal Sultan, Muhammad Akram Randhawa
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All pregnant women underwent a 75g oral glucose test in the 2nd trimester at 24-28 weeks of gestation. For this, the patients were sent to the MCH laboratory with overnight fasting where FBS was taken and they were given a 75 g glucose drink. Their blood sample was taken at 1-hour and 2-hour interval. Two or more elevated values out of the 3 blood samples were sufficient to diagnose GDM. Laboratory reports were reviewed and data was entered in the performa (attached) by the researcher. All the diagnosed patients were further evaluated for a 100g OGTT dose at the MCH laboratory with overnight fasting. Their FBS was studied and women were given a 100 g glucose drink and blood samples were drawn at an interval of 1, 2 and 3 hours respectively. Out of the 4 blood samples, two or more elevated values were sufficient to diagnose GDM. Lab reports were entered in the Performa. 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引用次数: 0

摘要

目的确定 75 克(口服葡萄糖耐量试验)OGTT 检测 GDM 的有效性,并将 100 克 OGTT 作为金标准。研究方法这是一项在伊斯兰堡巴基斯坦医学科学研究所母婴健康中心进行的横断面验证研究。研究时间为概要批准后的六个月。数据收集时间为 2019 年 3 月至 2019 年 9 月。所有 205 名患者均在知情同意的情况下参与了研究。患者的个人资料和医院登记号已按格式输入。通过病史采集和检查对患者进行初步评估。所有孕妇都在妊娠 24-28 周的后三个月接受了 75 克口服葡萄糖测试。为此,患者被送往妇幼保健院实验室,并在一夜禁食的情况下检测 FBS,同时给她们服用 75 克葡萄糖饮料。每隔 1 小时和 2 小时采集一次血样。3 份血样中有 2 份或 2 份以上数值升高,即可诊断为 GDM。研究人员对实验室报告进行了审查,并将数据填入执行表(附后)。所有确诊患者都在妇幼保健院实验室接受了 100 克 OGTT 剂量的进一步评估,并禁食一夜。研究人员研究了她们的 FBS,给女性患者饮用 100 克葡萄糖饮料,并分别在间隔 1、2 和 3 小时后抽取血液样本。在 4 份血样中,只要有两份或两份以上的数值升高,就足以诊断为 GDM。实验室报告已输入表格。结果在 205 名患者中,OGTT-75 g 诊断 GDM 的敏感性和特异性分别为 83.02% 和 82.83%。然而,OGTT-75 g 的阳性预测值和阴性预测值分别为 83.81% 和 82%。然而,OGTT-75 g 的总体诊断准确率为 82.93%。结论本研究结果表明,75 克 OGTT 对检测/诊断妊娠 DM 具有高度敏感性(83.02%)和特异性(82.83%)。先进的妊娠糖尿病筛查和诊断以及有效的治疗不仅能抑制围产期和孕产期的不良后果,还能挽救未来患糖尿病的儿童和母亲的生命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Validity Of 75gms OGTT For Detection Of GDM Keeping 100gms OGTT As Gold Standard
Objective: To determine the validity of 75gms (Oral Glucose Tolerance Test) OGTT for the detection of GDM keeping 100gms OGTT as the gold standard. Methodology: This was a Cross-sectional validation study done at the Mother and Child Health Centre, Pakistan Institute of Medical Sciences, Islamabad. The duration of the study was Six months from the approval of the synopsis. Data was collected from  March 2019 to September 2019. Informed consent for participating in the study was taken from all 205 patients. The patients' bio data along with the hospital registration number was entered pro forma. The patients were assessed initially by History taking and examination. All pregnant women underwent a 75g oral glucose test in the 2nd trimester at 24-28 weeks of gestation. For this, the patients were sent to the MCH laboratory with overnight fasting where FBS was taken and they were given a 75 g glucose drink. Their blood sample was taken at 1-hour and 2-hour interval. Two or more elevated values out of the 3 blood samples were sufficient to diagnose GDM. Laboratory reports were reviewed and data was entered in the performa (attached) by the researcher. All the diagnosed patients were further evaluated for a 100g OGTT dose at the MCH laboratory with overnight fasting. Their FBS was studied and women were given a 100 g glucose drink and blood samples were drawn at an interval of 1, 2 and 3 hours respectively. Out of the 4 blood samples, two or more elevated values were sufficient to diagnose GDM. Lab reports were entered in the Performa. Results: From a total of 205 patients, the sensitivity and specificity of OGTT-75 g for diagnosing GDM were 83.02% and 82.83%. However, positive predictive and negative predictive value for OGTT-75 g was 83.81% and 82% respectively. However, the overall diagnostic accuracy of OGTT-75 g was 82.93%. Conclusion: Results of this study showed that 75 gms OGTT is highly sensitive (83.02%) and specific (82.83%) for the detection/diagnosis of gestational DM. Advanced screening and diagnosis of gestational DM, and its effective treatment not only inhibit adverse perinatal and maternal outcomes but also save the lives of both child and mother from diabetes in future.
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