考虑到新陈代谢状况的妇女更年期植物神经紊乱替代疗法

Q4 Medicine
О.А. Taran, D. Konkov, O. Bulavenko, T. V. Lobastova, O.B. Malinina, N.M. Homon, I.R. Pyvniuk
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引用次数: 0

摘要

研究目的:研究使用 L-精氨酸和木糖醇药物替代复合疗法治疗更年期患者植物神经综合征的临床效果。材料与方法。该临床前瞻性研究纳入了 50 名绝经后早期患者,这些患者具有自然绝经、神经-植物神经和心理-情感表现的更年期综合征。根据生命延续策略,患者接受静脉注射 L-精氨酸(Tivortin 药物)和含电解质的木糖醇溶液(Xylat 药物),以保护血管内皮和纠正胰岛素抵抗,从而治疗更年期综合征。对所有妇女的改良库伯曼更年期指数、血清甘油三酯、胆固醇、高密度脂蛋白、低密度脂蛋白和极低密度脂蛋白水平进行了测定。检查在治疗开始前和治疗结束后 3 个月进行。生命延续治疗策略作为更年期患者植物神经综合征的替代综合疗法,有助于有效减少更年期综合征的表现。L-精氨酸和木糖醇联合疗法的优势表现在舒张压显著降低(p = 0.043)、库伯曼指数降低(p = 0.002)和血管运动症状平均得分降低(p = 0.02)。血清中的胰岛素水平(p = 0.00007)、HOMA 指数(p = 0.01)、低密度脂蛋白(p = 0.04)和甘油三酯(p = 0.03)也明显下降。在观察期间,所选疗法的耐受性良好。L-精氨酸和木糖醇联合疗法对绝经后早期伴有神经活力和精神情绪表现的更年期综合征有明显的临床效果,包括显著减少植物神经紊乱、稳定碳水化合物和脂质代谢。对于植物疗法无效、有更年期激素疗法禁忌或限制的更年期综合征患者,可以考虑将上述治疗策略作为替代疗法。这项研究结果表明,延长生命策略是安全的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alternative therapy of menopausal vegetative disorders in women taking the metabolic status into account
Research objectives: to study the clinical effectiveness of alternative complex therapy of vegetative syndrome in menopausal patients using L-arginine and xylitol drugs. Materials and methods. The clinical prospective study included 50 patients in the early postmenopausal period with natural menopause, neurovegetative and psychoemotional manifestations of the climacteric syndrome. According to the Life extension strategy, patients received intravenous L-arginine (Tivortin drug) and xylitol solution with electrolytes (Xylat drug) for endothelial protection and correction of insulin resistance in order to treat climacteric syndrome. Modified Kupperman menopausal index, serum triglyceride, cholesterol, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein levels were determined in all women. Examinations were performed before the start of therapy and 3 months after the end of treatment.Results. The Life extension therapeutic strategy as an alternative comprehensive therapy of the vegetative syndrome in menopausal patients contributed to a reliable reduction of the manifestations of the climacteric syndrome. The advantage of combined therapy involving L-arginine and xylitol was manifested in a significant decrease in diastolic blood pressure (p = 0.043); reduction of the Kupperman index (p = 0.002) and the average score of vasomotor symptoms (p = 0.02). There was also a significant decrease in the serum level of insulin (p = 0.00007), HOMA index (p = 0.01), low-density lipoproteins (p = 0.04), and triglycerides (p = 0.03). The selected therapy was well tolerated during the observation period.Conclusions. The combined therapy involving L-arginine and xylitol in the early postmenopausal period with neurovegetative and psychoemotional manifestations of the climacteric syndrome had a pronounced clinical effect, which consisted in a significant reduction of vegetative disorders and stabilization of carbohydrate and lipid metabolism. The given therapeutic strategy can be considered as an alternative therapy in patients with climacteric disorders when phytotherapy is ineffective and when there are contraindications or limitations to menopausal hormone therapy. The results of this study showed the safety of the Life extension strategy.
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来源期刊
Reproductive Endocrinology
Reproductive Endocrinology Medicine-Obstetrics and Gynecology
CiteScore
0.50
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0.00%
发文量
13
审稿时长
8 weeks
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