一种新的硫代氨基甲酸及其 3d 金属配合物：合成、结构和抗氧化研究

IF 1 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Research Pub Date : 2023-11-01 DOI:10.1177/17475198231216422

Ianina Graur, Tatiana Bespalova, Vasilii Graur, V. Tsapkov, O. Garbuz, E. Melnic, Pavlina Bourosh, A. Gulea

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引用次数: 0

摘要

合成了 2-[1-氧代-1-(哌啶-1-基)丙-2-亚基]-N-(丙-2-烯-1-基)硫代肼(HL)及其六种配位化合物[Cu(L)X](X = Cl- (1)，NO3- (2))，[Cu(A)(L)NO3](A = 1,10-Phen (3)，2,2′-Bpy (4))、[Ni(HL)2](NO3)2 (5) 和 [Fe(L)2]Cl (6) 的合成，并通过元素分析、傅立叶变换红外光谱 (FTIR)、核磁共振 (NMR) 和单晶 X 射线晶体学进行了表征。与大多数其他络合物相比，无配位硫代氨基甲酸 HL 对 2,2′-叠氮-双（3-乙基苯并噻唑啉-6-磺酸）阳离子自由基具有更高的抗氧化活性。络合物 5 的活性最高，其活性超过了 HL，接近于作为抗氧化剂用于医药的 trolox。在[Cu(L)NO3]络合物的内球中引入 N-杂芳基（1,10-菲罗啉和 2,2′-联吡啶）并不会提高抗氧化活性。

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A new thiosemicarbazone and its 3d metal complexes: Synthetic, structural, and antioxidant studies

2-[1-Oxo-1-(piperidin-1-yl)propan-2-ylidene]- N-(prop-2-en-1-yl)hydrazinecarbothioamide (HL) and its six coordination compounds [Cu(L)X] (X = Cl− (1), NO3− (2)), [Cu(A)(L)NO3](A = 1,10-Phen (3), 2,2′-Bpy (4)), [Ni(HL)2](NO3)2 (5), and [Fe(L)2]Cl (6) are synthesized and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and single-crystal X-ray crystallography. Uncoordinated thiosemicarbazone HL shows higher antioxidant activity against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS+•) cation radicals compared with most of the other complexes. Complex 5 is the most active and its activity exceeds that of HL and is close to that of trolox, which is used in medicine as an antioxidant. The introduction of N-heteroaromatic bases (1,10-phenanthroline and 2,2′-bipyridine) into the inner sphere of the complex [Cu(L)NO3] did not lead to an increase in antioxidant activity.

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来源期刊

Journal of Chemical Research CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

1.0 months

期刊介绍： The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry. Established in 1977 as a joint venture by the British, French and German chemical societies it maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted. Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes.