测定喹硫磷的急性毒性和亚致死浓度对黑线鲈蛋白质和脂质过氧化的影响

Q4 Pharmacology, Toxicology and Pharmaceutics

Toxicology International Pub Date : 2023-11-03 DOI:10.18311/ti/2023/v30i4/33533

Chinnu Shaji, Suma M. Abraham, Joe Prasad Mathew

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引用次数: 0

摘要

喹硫磷是一种用于农业的有机磷，被认为对非目标生物具有潜在的危险影响。本研究旨在确定喹硫磷（一种有机磷农药）对黑线鲈鱼 96 小时的中位致死浓度（LC50）。经测定，喹硫磷对黑线鲈 96 小时的半数致死浓度为 3.65 微升/升。研究还重点关注了接触亚致死浓度的喹硫磷 24 小时后对大脑和肌肉组织中蛋白质和脂质过氧化率的直接影响。研究发现，接触喹硫磷 24 小时后，两种组织中的蛋白质都在减少，而脂质过氧化率却在增加。通过估算抗氧化酶超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性，还发现喹硫磷能够损害非目标生物的抗氧化防御机制，从而增加氧化应激。

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Determination of Acute Toxicity and the Effect of Sub-Lethal Concentration of Quinalphos on Protein and Lipid Peroxidation in Oreochromis niloticus

Quinalphos is an organophosphate used in agriculture that is considered to have potential hazardous effects on nontarget organisms. The present study was designed to determine the median lethal concentration (LC50) of quinalphos (an organophosphate pesticide) on the fish, Oreochromis niloticus, for 96 hours. The LC50 value of quinalphos on Oreochromis niloticus for 96 hours was determined as 3.65 μl/L. The study also focuses on the immediate effect of exposure to sub-lethal concentrations of quinalphos on protein and lipid peroxidation rate after 24 hours in brain and muscle tissues. Protein was found to be decreasing while lipid peroxidation rate increased in both tissues after 24 hours of exposure. By the estimation of antioxidant enzymes Superoxide Dismutase (SOD) and Catalase (CAT) activity, it was also identified that quinalphos is capable of impairing the antioxidant defense mechanism of the non-target organism and thereby increase the oxidative stress.

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来源期刊

Toxicology International Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Toxicology International is a peer-reviewed International Research Journal published bi-annually by the Society of Toxicology, India. The Journal is concerned with various disciplines of Toxicology including man, animals, plants and environment and publishes research, review and general articles besides opinions, comments, news-highlights and letters to editor.