Formulation of Gel Preparations of Ethanol Extract of Indian Strawberry (Duchesnea indica (Jacks.) Focke.)

The anti-inflammatory activity of Indian strawberry leaves is 0.31 percent DAI. For the treatment of inflammation, gel formulations are selected as effective penetration agents. The purpose of this work was to manufacture and test a pharmaceutically stable gel formulation of ethanol extract of Indian strawberry (Duchesnea indica (Jacks.) Focke] leaf with anti-inflammatory properties. This experimental study approach involved developing four formulas: F1 with 3% NaCMC, F2 with 4% NaCMC, F3 with 8% HPMC, and F4 with 9% HPMC. Then, the next test was evaluate the physical stability of the formulation using the following test parameters: organoleptic, pH, homogeneity, spreadability, and viscosity at 5°C and 35°C. The organoleptic test revealed that there was no difference between the four formulae in the color, odor, and consistency series. Each of the pH formulae that passed the pH test were suitable for topical application to the skin. For the homogeneity test all formulas are homogeneous. The best dispersion for the dispersion test was found in formulas 2, 3, and 4. Based on the rheogram, F1, F2, F3, and F4 had pseudoplastic flow characteristics. According to the results of the research conducted, the ethanol extract of Indian strawberry leaves can be formed into gel formulations based on HPMC and NaCMC. The gel formulation formula for ethanol extract of Indian strawberry leaves is pharmaceutically stable.