乳腺癌组织中肿瘤基质细胞、瘤周微血管和孤立肿瘤细胞簇的 PD-L1 表达特征及其与乳腺癌临床和形态学特征的相关性

Q4 Medicine

Siberian journal of oncology Pub Date : 2023-11-15 DOI:10.21294/1814-4861-2023-22-5-71-83

E. Zubareva, M. A. Senchukova, T. Karmakova, N. V. Zaitsev

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引用次数: 0

摘要

目的：研究PD-L1在乳腺癌（Bc）组织中的肿瘤基质细胞、瘤周微血管和分离的肿瘤细胞簇中的表达特征及其与Bc临床和形态学特征的相关性。研究纳入了 158 例新确诊的浸润性乳腺癌患者。采用免疫组化方法研究PD-L1的表达。瘤周微血管中PD-L1的表达分别出现在41.4%的T1-2和61.7%的T3-4病例中（P=0.020），以及39.8%的N0-1和51.7%的N2-3病例中（P=0.008）。7%的I-IIb期、IIIa-IIIc期和IV期病例（P=0.011）；30.3%、26.2%、40.0%和52.5%的T1、T2、T3和T4期病例（P=0.040）；28.2%和45.5%的N0-1期和N2-3期病例（P=0.030）。在结节型和弥漫型 BC 中分别有 28.8% 和 55.0% 的病例（p=0.003），在早期、局部晚期和转移性 BC 中分别有 17.6%、52.5% 和 75.0% 的病例（p<0.001），在 T1、T2 和 T4 中分别有 21.2%、28.7%、80.0% 和 55.0% 的病例（p=0.003）。在T1、T2、T3和T4的病例中分别占21.7%、35.3%、51.4%和55.0%（P=0.002），在N0、N1、N2和N3的病例中分别占21.2%、28.7%、80.0%和55.0%（P=0.005），在PR阴性和阳性的病例中分别占49.0%和29.0%（P=0.014），在HER2阴性和HER2阳性的病例中分别占30.3%和52.8%（P=0.014）。数据表明，PD-L1表达与BC进展之间存在关系。测定瘤周微血管和孤立肿瘤细胞簇中的 PD-L1 表达以及该标记物的核表达，可用于明确疾病的预后。

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The features of PD-L1 expression in tumor stromal cells, peritumoral microvessels and isolated clusters of tumor cells in breast cancer tissue and their correlation with clinical and morphological characteristics of breast cancer

Objective: to study the features of PD-L1 expression in tumor stromal cells, peritumoral microvessels, and isolated clusters of tumor cells in breast cancer (Bc) tissue and their correlation with the clinical and morphological characteristics of Bc.Material and Methods. The study included 158 patients with newly diagnosed invasive BC. PD-L1 expression was studied by immunohistochemistry. statistical analysis was performed using statistica 12.0 software.Results. PD-L1 expression in peritumoral microvessels occurred in 41.4 and 61.7 % of cases with t1–2 and T3–4 (p=0.020), and in 39.8 and 51.7 % of cases with N0–1 and N2–3 (p=0.008), respectively. In isolated clusters of tumor cells, the marker expression was observed in 28.0 and 52.5 % of cases in nodular and diffuse forms of BC (p=0.005); in 25.9, 39.3 and 66.7 % of cases at stages I–IIb, IIIa–IIIc and IV (p=0.011); in 30.3, 26.2, 40.0 and 52.5 % of cases in T1, T2, T3 and T4 (p=0.040); and in 28.2 and 45.5 % of cases in N0–1 and N2–3 (p=0.030), respectively. Nuclear expression of PD-L1 was also detected in stromal cells, and was observed in 28.8 and 55.0 % of cases with nodular and diffuse forms of BC (p=0.003), in 17.6, 52.5 and 75.0 % of cases in early, locally advanced and metastatic BC (p<0.001), in 21.2, 28.7, 80.0 and 55.0 % of cases in T1, T2, T3 and T4 (p=0.002), in 21.7, 35.3, 51.4 and 55.0 % of cases with N0, N1, N2 and N3 (p=0.005), in 49.0 and 29.0 % of cases with negative and positive status of PR (p=0.014), in 30.3 and 52.8 % of cases with HER2-negative and HER2-positive BC status (p=0.014), respectively.Conclusion. The data indicate the relationship between PD-L1 expression and BC progression. The determination of PD-L1 expression in peritumoral microvessels and isolated tumor cell clusters, as well as nuclear expression of the marker, can be used to clarify the prognosis of the disease.

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来源期刊

Siberian journal of oncology Medicine-Oncology

CiteScore

0.40

自引率

0.00%

发文量

117

审稿时长

8 weeks

期刊介绍： The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets