具有β片构象调制能力的纳米级钴官能化斯特兰堡型磷钼酸盐在抗淀粉样蛋白折叠中的作用

IF 3.1 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganics Pub Date : 2023-11-18 DOI:10.3390/inorganics11110442

M. Wang, J. Hua, Pei Zheng, Yuanzhi Tian, Shaodan Kang, Junjun Chen, Yifan Duan, Xiang Ma

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引用次数: 0

摘要

几十年来，具有β片状结构的淀粉样β肽（Aβ）错误折叠聚集体一直与阿尔茨海默病（AD）的发生和发展有关。因此，调节 Aβ 的错误折叠模式被认为是一种重要的抗淀粉样蛋白错误折叠策略。一种基于{Co(H2O)4}2+复合物和[P2Mo5O23]6-片段的多氧金属盐 K8{[Co(H2O)4][HP2Mo5O23]2}-8H2O（缩写为 CoPM）被合成出来，并构建了其结构、的合成，并利用元素分析、单晶 X 射线衍射 (SXRD)、红外光谱、紫外光谱、键价和 (Σs)计算以及粉末 X 射线衍射 (PXRD) 对其结构进行了表征。结构分析表明，CoPM 的主要成分是由夹在两片 [P2Mo5O23]6- 之间的 [Co(H2O)4]2+ 组成的纳米级多氧阴离子。值得注意的是，研究表明 CoPM 能有效调节 Aβ 聚集体的 β-片状富构象。

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A Nanoscale Cobalt Functionalized Strandberg-Type Phosphomolybdate with β-Sheet Conformation Modulation Ability in Anti-Amyloid Protein Misfolding

For decades, amyloid β-peptide (Aβ) misfolding aggregates with β-sheet structures have been linked to the occurrence and advancement of Alzheimer’s disease (AD) development and progression. As a result, modulating the misfolding mode of Aβ has been regarded as an important anti-amyloid protein misfolding strategy. A polyoxometalate based on {Co(H2O)4}2+ complex and [P2Mo5O23]6− fragments, K8{[Co(H2O)4][HP2Mo5O23]2}·8H2O (abbreviated as CoPM), has been synthesized and structurally characterized using elemental analysis, single-crystal X-ray diffraction (SXRD), IR, UV spectra, bond valence sums (Σs) calculation, and powder XRD (PXRD). CoPM’s primary component, as revealed by structural analysis, is a nanoscale polyoxoanion made of [Co(H2O)4]2+ sandwiched between two [P2Mo5O23]6− pieces. Notably, it is demonstrated that CoPM efficiently modulates Aβ aggregates’ β-sheet-rich conformation.

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来源期刊

Inorganics Chemistry-Inorganic Chemistry

CiteScore

2.80

自引率

10.30%

发文量

193

审稿时长

6 weeks

期刊介绍： Inorganics is an open access journal that covers all aspects of inorganic chemistry research. Topics include but are not limited to: synthesis and characterization of inorganic compounds, complexes and materials structure and bonding in inorganic molecular and solid state compounds spectroscopic, magnetic, physical and chemical properties of inorganic compounds chemical reactivity, physical properties and applications of inorganic compounds and materials mechanisms of inorganic reactions organometallic compounds inorganic cluster chemistry heterogenous and homogeneous catalytic reactions promoted by inorganic compounds thermodynamics and kinetics of significant new and known inorganic compounds supramolecular systems and coordination polymers bio-inorganic chemistry and applications of inorganic compounds in biological systems and medicine environmental and sustainable energy applications of inorganic compounds and materials MD