9-苯基-2,3,4,5,6,7,8,9-八氢-1H-硒氧蒽纳米形式对白鼠生殖功能的影响

Journal Biomed Pub Date : 2023-11-20 DOI:10.33647/2713-0428-19-3e-85-89

O. V. Buyuklinskayа, S. M. Napalkova, E. D. Kubasova, D. S. Makarova

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引用次数: 0

摘要

尽管现代治疗方法多种多样，但俄罗斯和全球的不孕不育率仍然居高不下。在本实验研究中，我们研究了一种基于硒氧蒽衍生物和环糊精的纳米制剂在米非司酮给药后对雌性白种大鼠繁殖的影响。硒氧蒽以 0.35 毫克/千克和 0.7 毫克/千克的剂量胃内注射 5 天，可提高动物的生殖活性。

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Influence of a Nanoform of 9-phenyl-2,3,4,5,6,7,8,9-octahydro-1H-selenoxanthene on the Reproductive Function of White Rats

Despite the diversity of modern treatment methods, infertility rates remain high both in Russian and globally. In the present experimental study, we study the effect of a nanopreparation based on a selenoxanthene derivative and cyclodextrin on the reproduction of white outbred rats (females) after the administration of mifepristone. Selenoxanthene at a dose of 0.35 mg/kg and 0.7 mg/kg intragastrically for 5 days increased the reproductive activity of animals.

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Journal Biomed

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