妊娠糖尿病患者体内 Th17/Treg 细胞相关因子的检测和临床意义

Jinjin Qin, Bei Wang, Chenyuan Cao, Yakun Zhao, Jing Wang, Hongli Wu
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引用次数: 0

摘要

目的研究妊娠期糖尿病(GDM)患者体内 Th17/Treg 细胞相关因子的检测及其临床意义。方法:采用回顾性队列研究方法:本研究采用回顾性队列研究方法,收集2018年1月-2022年12月在河北大学附属医院住院并确诊为GDM的42例患者以及同期正常妊娠的42例患者的临床资料。采用放射免疫法检测患者外周血中Th17/Treg表达水平及代谢相关指标。结果显示GDM组患者血清中Th17相对表达量明显高于对照组,Treg水平明显低于对照组(P<0.05);GDM组患者FBG、FINS、2hBG、TC、TG、HOMA-IR水平明显高于对照组,HOMA-β水平明显低于对照组(P<0.05)。结论GDM患者Th17/Treg细胞比例失调可能与其疾病进展和预后有关,为GDM的临床治疗提供了新的思路和策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Detection and Clinical Significance of Th17/Treg Cell-Related Factors in Patients with Gestational Diabetes Mellitus
Objective: To investigate the detection of Th17/Treg cell-related factors in patients with gestational diabetes mellitus (GDM) and its clinical significance. Methods: In this study, a retrospective cohort research method was used to collect the clinical data of 42 patients who were hospitalized in the Affiliated Hospital of Hebei University and received the diagnosis of GDM from January 2018 to December 2022, as well as 42 patients with normal pregnancies during the same period. The Th17/Treg expression levels and metabolism-related indexes in the peripheral blood of patients were detected by radioimmunoassay. Results: The relative expression of Th17 in the serum of patients in the GDM group was significantly higher than that of the control group, and the level of Treg was significantly lower than that of the control group (P < 0.05); the levels of FBG, FINS, 2hBG, TC, TG and HOMA-IR of the patients in the GDM group were significantly higher than that of the control group, and the level of HOMA-β was significantly lower than that of the control group (P < 0.05). Conclusion: The imbalance of the Th17/Treg cell ratio in patients with GDM may be related to their disease progression and prognosis, providing new ideas and strategies for the clinical treatment of GDM.
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