{"title":"从毛细血管到组织的脑氧运输数学建模","authors":"A. Kovtanyuk, A. Chebotarev, Reneé Lampe","doi":"10.3389/fams.2023.1257066","DOIUrl":null,"url":null,"abstract":"A non-linear model of oxygen transport from a capillary to tissue is considered. The model takes into account the convection of oxygen in the blood, its diffusion transfer through the capillary wall, and the diffusion and consumption of oxygen in tissue. In the current work, a boundary value problem for the oxygen transport model is studied. The existence theorem is proved and a numerical algorithm is constructed and implemented. The numerical experiments studying the effect of low hematocrit and reduced blood flow rate on cerebral hypoxia in preterm infants are conducted.","PeriodicalId":507585,"journal":{"name":"Frontiers in Applied Mathematics and Statistics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mathematical modeling of cerebral oxygen transport from capillaries to tissue\",\"authors\":\"A. Kovtanyuk, A. Chebotarev, Reneé Lampe\",\"doi\":\"10.3389/fams.2023.1257066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A non-linear model of oxygen transport from a capillary to tissue is considered. The model takes into account the convection of oxygen in the blood, its diffusion transfer through the capillary wall, and the diffusion and consumption of oxygen in tissue. In the current work, a boundary value problem for the oxygen transport model is studied. The existence theorem is proved and a numerical algorithm is constructed and implemented. The numerical experiments studying the effect of low hematocrit and reduced blood flow rate on cerebral hypoxia in preterm infants are conducted.\",\"PeriodicalId\":507585,\"journal\":{\"name\":\"Frontiers in Applied Mathematics and Statistics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Applied Mathematics and Statistics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fams.2023.1257066\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Applied Mathematics and Statistics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fams.2023.1257066","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Mathematical modeling of cerebral oxygen transport from capillaries to tissue
A non-linear model of oxygen transport from a capillary to tissue is considered. The model takes into account the convection of oxygen in the blood, its diffusion transfer through the capillary wall, and the diffusion and consumption of oxygen in tissue. In the current work, a boundary value problem for the oxygen transport model is studied. The existence theorem is proved and a numerical algorithm is constructed and implemented. The numerical experiments studying the effect of low hematocrit and reduced blood flow rate on cerebral hypoxia in preterm infants are conducted.
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