用于偏头痛预防性治疗的抗 CGRP mAbs:全球概况回顾与成本节约分析

IF 0.8 Q4 PHARMACOLOGY & PHARMACY
Andrea Zovi, R. Lasala, Francesco Ferrara, Roberto Langella, Antonio Vitiello, Michela Sabbatucci, Umberto Maria Musazzi
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引用次数: 0

摘要

目的:偏头痛是一种发病率很高的神经系统疾病。新型降钙素基因相关肽及其配体选择性单克隆抗体(抗降钙素基因相关肽 mAbs)在预防偏头痛方面疗效显著,已在美国和欧盟上市。本研究旨在收集有关抗 CGRP mAbs 有效性的真实证据,进行成本节约分析,并比较在美国和欧洲市场上销售的抗 CGRP mAbs 药物的性能。研究方法2022年12月31日在PubMed数据库中进行了文献综述;从美国国家数据库中提取了抗CGRP mAbs单位剂量的成本。结果结果证实了抗 CGRP mAbs 的疗效和良好耐受性,并确定了购买价格的差异。事实上,所有提取的研究结果表明,所有抗CGRP mAbs在减少每月偏头痛天数方面都具有保护性风险因素暴露,而成本分析表明,与其他抗CGRP mAbs相比,使用eptinezumab,每季度每位患者可节省至少425美元的成本。结论在同等疗效和同等安全性的情况下,抗 CGRP mAbs 的处方应考虑到协商确定的成本,确保为患者提供最佳治疗,同时尽可能减少对医疗服务资源的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-CGRP mAbs for the Preventive Treatment of Migraine: An Overview Review and a Cost Saving Analysis in the Global Scenario
Objectives: Migraine is a neurological disease with a high frequency of incidence. The new monoclonal antibodies selective for the calcitonin gene-related peptide and its ligand (anti-CGRP mAbs) have been marketed both in the USA and EU based on the positive efficacy results in the prevention of migraine. This search has been carried out with the aim of collecting real-world evidence on the effectiveness of anti-CGRP mAbs, performing a cost-savings analysis, and comparing performances among anti-CGRP mAbs medicines marketed in the American and European market. Methods: The literature review has been performed in PubMed database on 31 December 2022; the cost of the unitary dose of anti-CGRP mAbs has been extracted consulting an American national database. Results: The results confirm efficacy and good tolerability of anti-CGRP mAbs, determining a difference in the purchase price. In fact, all extracted studies showed a protective risk factor exposure in monthly migraine days reduction for all the anti-CGRP mAbs, whereas the cost analysis showed that using eptinezumab, in a quarter there is a cost saving of at least $425 per patient, compared with the other anti-CGRP mAbs. Conclusions: With equal efficacy and equal safety, anti-CGRP mAbs should be prescribed also regard to the cost established at the negotiation, making sure to guarantee the best treatment to the patients, but at the same time impacting as little as possible to the healthcare services resources.
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来源期刊
Hospital Pharmacy
Hospital Pharmacy PHARMACOLOGY & PHARMACY-
CiteScore
1.70
自引率
0.00%
发文量
63
期刊介绍: Hospital Pharmacy is a monthly peer-reviewed journal that is read by pharmacists and other providers practicing in the inpatient and outpatient setting within hospitals, long-term care facilities, home care, and other health-system settings The Hospital Pharmacy Assistant Editor, Michael R. Cohen, RPh, MS, DSc, FASHP, is author of a Medication Error Report Analysis and founder of The Institute for Safe Medication Practices (ISMP), a nonprofit organization that provides education about adverse drug events and their prevention.
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