牛膝种子提取物对小鼠肝组织结构和胎儿的影响

Samira Musa Sasi, Nagia Al ghoul, N. Awayn, Ahmed El ghoul, R. Prastiya
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引用次数: 0

摘要

牛膝是治疗多种疾病的常用植物之一。其有效化合物具有制药和药用特性。本研究的目的是确定禾本科植物种子的水提取物对小鼠体重、肝脏重量、天门冬氨酸氨基转移酶(AST)、丙氨酸转氨酶(ALT)、肝脏组织学结构以及经处理小鼠所怀胎儿大小的影响。16 只成年雄性小鼠被分为两组,每组 8 只。第一组(对照组)口服蒸馏水,第二组口服哈马拉种子水提取物,剂量为 300 毫克/千克体重,连续三周。治疗结束后,称量并杀死每组的六只雄性小鼠。提取肝脏、称重并测量其酶含量。同时,制备肝脏切片进行组织学检查。结果显示,与对照组相比,治疗组小鼠的体重下降,胎儿的平均体重显著增加,肝组织结构也发生了明显变化。提取物对处理组小鼠的胎儿体长、肝脏重量和肝脏酶(谷草转氨酶和谷丙转氨酶)没有影响。 应开展进一步研究,以确定不影响体内任何器官的安全剂量,从而将其用于治疗多种疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Peganum harmala seeds extract on the hepatic tissue structure and fetus of mice
Peganum harmala is one of the most used plants for the treatment of many diseases. Its effective compounds have pharmaceutical and medicinal properties. This study aims to determine the effect of aqueous extract of harmala plant seeds on body and liver weight, aspartate aminotransferase (AST), alanine transaminase (ALT), and the histological structure of liver of mice, as well as the size of the fetuses sired by treated mice. Sixteen adult male mice were divided into two groups of eight. The first group (control) was given distilled water orally, while the second group received the aqueous extract of harmala seeds at a dose of 300 mg/kg bw for three weeks. three untreated females were housed with one treated male for mating. At the end of the treatment, six male mice of each group were weighed and killed. Liver was extracted, weighed and its enzymes were measured. Also, sections of the liver were prepared for histological examination. The results showed a decrease in the body weight of the treated mice and a significant increase in the average weight of the fetuses compared with the control group, as well as marked changes in the hepatic tissue structure. There was no impact of the extract on fetal body length, liver weight and hepatic enzymes (AST and ALT) of treated mice.  Further studies should be conducted to determine a safe dose that does not affect any organ in the body, so that it can be used for the treatment of many diseases.
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