5-FU/ASA 杂交化合物的合成和硅学药物相似性建模

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-11-27 DOI:10.3390/m1745

Wilson Castrillón-López, Andrés F. Yepes, Wilson Cardona-Galeano

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引用次数: 0

摘要

以点击化学为关键步骤合成了一系列 5-FU-ASA 杂交化合物，并取得了良好的收率。通过光谱分析阐明了这些化合物的结构。最后，还对每个合成的杂交化合物的最佳药代动力学特征进行了估计。综上所述，杂交化合物 4a-h 可作为进一步开展癌症干预治疗药理学研究的起点。

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Synthesis and In Silico Drug-Likeness Modeling of 5-FU/ASA Hybrids

A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each synthetized hybrid. Taken together, hybrids 4a–h could be used as starting points for further pharmacological studies concerning therapeutic cancer intervention.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)