循环肿瘤细胞的临床应用

IF 0.8 4区生物学 Q4 GENETICS & HEREDITY

Medizinische Genetik Pub Date : 2023-11-29 DOI:10.1515/medgen-2023-2056

N. Stoecklein, Julia Oles, A. Franken, Hans Neubauer, L. Terstappen, R. Neves

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引用次数: 0

摘要

摘要本综述旨在全面概述循环肿瘤细胞（CTC）分析的现状及其对上皮癌患者的临床意义。综述探讨了 CTC 检测方法的进展、临床应用及其面临的挑战。通过研究该领域的重要研究成果，这篇综述为读者了解 CTC 分析的发展状况及其对临床实践的潜在影响奠定了坚实的基础。对 CTCs 的全面分析为肿瘤生物学、治疗反应、最小残留病检测和预后评估提供了宝贵的见解。此外，该综述还强调了 CTC 作为非侵入性生物标记物在个性化医疗和疗效监测方面的潜力。尽管 CTC 研究取得了进展，但仍存在一些挑战，如标准化、验证和与常规临床实践的整合。综述最后讨论了未来的发展方向以及 CTC 分析对改善患者预后和指导上皮癌治疗决策的潜在影响。

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Clinical application of circulating tumor cells

Abstract This narrative review aims to provide a comprehensive overview of the current state of circulating tumor cell (CTC) analysis and its clinical significance in patients with epithelial cancers. The review explores the advancements in CTC detection methods, their clinical applications, and the challenges that lie ahead. By examining the important research findings in this field, this review offers the reader a solid foundation to understand the evolving landscape of CTC analysis and its potential implications for clinical practice. The comprehensive analysis of CTCs provides valuable insights into tumor biology, treatment response, minimal residual disease detection, and prognostic evaluation. Furthermore, the review highlights the potential of CTCs as a non-invasive biomarker for personalized medicine and the monitoring of treatment efficacy. Despite the progress made in CTC research, several challenges such as standardization, validation, and integration into routine clinical practice remain. The review concludes by discussing future directions and the potential impact of CTC analysis on improving patient outcomes and guiding therapeutic decision-making in epithelial cancers.

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来源期刊

Medizinische Genetik Medicine-Genetics (clinical)

CiteScore

1.40

自引率

9.10%

发文量

审稿时长

>12 weeks

期刊介绍： medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter. medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community. In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.