15% 三氯醋酸换肤、35% 乙醇酸换肤和 Q 开关 Nd-YAG 激光对黄斑淀粉样变性患者疗效和安全性的前瞻性比较研究

Q3 Medicine

Journal of Cutaneous and Aesthetic Surgery Pub Date : 2023-11-30 DOI:10.4103/jcas.jcas_55_23

Aditi Vaghasia, Shruti Kamat, Kajal Kansara, J. Dharmender, Bela Shah

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引用次数: 0

摘要

黄斑淀粉样变性（MA）患者的皮肤外观难看，影响了患者的生活质量，治疗这种疾病一直是个难题。比较 15%三氯乙酸（TCA）换肤、35%乙醇酸（GA）换肤和 Q 开关 Nd-YAG 激光治疗黄斑淀粉样变性病的有效性和安全性。该研究为开放性前瞻性研究，为期两年，在符合标准后随机分为三组。A组：15% TCA换肤；B组：35% GA换肤；C组：Q开关Nd-YAG激光：C组：Q开关Nd-YAG激光。每个月重复一次，共进行六次。每次就诊时，对患者的以下参数进行评分：颜色评分、视觉模拟评分（VAS）、医生总体评估（PGA）量表、主观改善情况和不良反应。共有 75 名患者（每组 25 人）完成了治疗。研究对象的平均年龄为（35.68 ± 9.8）岁，男女比例为 11.5:1。A 组患者的体色评分平均变化较大（1.68），其次是 C 组（1.4），再次是 B 组（1.16）。主观改善、VAS 和 PGA 的结果相似。不良反应在 A 组较多，其次是 C 组，再次是 B 组。 TCA 脱皮疗法的效果优于 Nd-YAG 激光和乙醇酸脱皮疗法。TCA-peel 具有成本效益和良好的可接受性，应被视为一种治疗方式。

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A prospective comparative study of efficacy and safety of 15% trichloroacetic acid peel, 35% glycolic acid peel and Q-switched Nd-YAG laser in patients of macular amyloidosis

The unappealing appearance of skin in macular amyloidosis (MA) interferes with the patient’s quality of life, and treating the condition has been challenging. To compare the efficacy and safety of 15% trichloroacetic acid (TCA) peel, 35% glycolic acid (GA) peel, and Q-switched Nd-YAG Laser in MA. Open, prospective study was conducted over 2 years, where after fulfilling the criteria, randomization was done into three groups. Group A: 15% TCA peel; Group B: 35% GA peel; Group C: Q-switched Nd-YAG Laser. Procedures were repeated at monthly intervals for six sittings. On each visit, patients were scored on the following parameters: color score, visual analog score (VAS), physician global assessment (PGA) scale, subjective improvement, and adverse effects. A total of 75 patients (25 patients in each group) completed the treatment. The mean age of study-population was 35.68 ± 9.8 years, with female to male ratio of 11.5:1. The mean change in color score (1.68) was more by Group A, followed by Group C (1.4), followed by Group B (1.16). Similar results were noted by subjective improvement, VAS, and PGA. Adverse events were more in Group A, followed by Group C, followed by Group B. No patient showed permanent adverse events. TCA-peel showed superior results over Nd-YAG laser and glycolic-acid peel. TCA-peel being cost-effective with excellent acceptability should be considered a treatment modality.

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来源期刊

Journal of Cutaneous and Aesthetic Surgery Medicine-Surgery

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

29 weeks

期刊介绍： The journal will cover aspects of Dermatosurgery and Aesthetic surgery, including cutaneous surgical procedures, lasers, light based treatments and aesthetic treatments. Authors of articles addressing topics such as skin tumours, pigmentary disorders, histopathology, diagnostic techniques, drugs, applications of cosmeceuticals surgical aspects, including pre and post procedural care are highly encouraged to submit with us. The journal also publishes articles on topics in allied specialities suh as plastic surgery, maxillofacial surgery vascular surgery, oculoplastic surgery etc. that are relevant to Dermatosurgery. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed Original Research Articles, Systematic reviews, Narrative Reviews, Case reports, Innovations and Debates. Letters to the editor, practice points, pearls in cutaneous and aesthetic surgery, quiz page, images, novel techniques, newer uses of instruments and video presentations and ethical aspects of cutaneous and aesthetic surgery are also invited.