用温和还原法合成的氧化石墨烯提高了对人类宫颈癌的抗肿瘤功效

IF 2.9 4区医学 Q1 Medicine

Journal of biomedical nanotechnology Pub Date : 2023-12-01 DOI:10.1166/jbn.2023.3725

Naiwei Li, Dinesh Kumar Sain, Hadi Jabbari, Somayeh Vafaei, Guluzar Ozbolat, Ramirez-Coronel Andres Alexis, Akhavan-Sigari Reza

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引用次数: 0

摘要

本研究以氧化石墨烯（GO）为原料，采用不同还原度的温和方法合成制备。我们使用傅立叶变换红外光谱（FTIR）、拉曼光谱（Raman Spectroscopy）、X射线光电子能谱（XPS）、紫外可见光谱（UV-Vis）、透射电子显微镜（TEM）和EDS光谱来表征其结构和形态。细胞实验结果表明，还原型 GO 在激光照射下具有显著的细胞毒性活性。此外，在近红外激光照射下，还原型 GO 可通过光热和光毒双重效应杀死肿瘤细胞，可用作光热疗法

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Graphene Oxide Synthesized Using Mild Reduction Method Improved the Anti-Tumor Efficacy on Human Cervical Cancer

In the current study, graphene oxide (GO) as raw material synthesized using different reduction degrees prepared by a mild method. We used Fourier transform infrared spectroscopy (FTIR), Raman Spectroscopy (Raman), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible spectroscopy (UV-Vis), transmission electron microscopy (TEM) and EDS spectroscopy to characterize its structure and morphology. The results of cell experiments showed the significant cytotoxicity activity of reduced GO under laser irradiation. In addition, reduced GO kills tumor cells through the dual effects of photothermal and phototoxicity under near-infrared (NIR) laser irradiation and can be used as photothermal therapy

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来源期刊

Journal of biomedical nanotechnology 医学-纳米科技

CiteScore

4.30

自引率

17.20%

发文量

145

审稿时长

2.3 months

期刊介绍： Information not localized