Garavelas Athanasios, Michalopoulos Efstathios, Mallis Panagiotis, Nikitos Eros
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The results of this study clearly showed that all participants were characterized by elevated levels of FSH and LH and reduced levels of E2 and AMH, prior to the PL injection. However, the levels of all hormones started to change after the 1st month of follow-up monitoring. Moreover, 40% of the participants conceived successfully either by natural way or after in vitro Fertilization (IVF). Considering these, the intraovarian injection of autologous PL exhibited promising evidence regarding the altering of hormone levels at physiological values. Moreover, the contained PL growth factors were implicated in angiogenesis promotion and also in toleration of the inflammatory microenvironment, regulating positively ovarian function. In conclusion, the intraovarian autologous PL injection is considered a safe, effective, and tolerable therapeutic strategy in women with POR or POI. Moreover, the results of this study were very encouraging, especially for the women with infertility issues, who want their genetic offspring.","PeriodicalId":505668,"journal":{"name":"Clinical Journal of Obstetrics and Gynecology","volume":"187 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Rejuvenation of Ovarian Function after Autologous Platelet Lysate Injection: Promising Evidence from Confirmed Cases\",\"authors\":\"Garavelas Athanasios, Michalopoulos Efstathios, Mallis Panagiotis, Nikitos Eros\",\"doi\":\"10.29328/journal.cjog.1001153\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Intraovarian injection of autologous Platelet Lysate (PL) can be considered a potential therapeutic strategy for ovarian function rejuvenation. 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Moreover, 40% of the participants conceived successfully either by natural way or after in vitro Fertilization (IVF). Considering these, the intraovarian injection of autologous PL exhibited promising evidence regarding the altering of hormone levels at physiological values. Moreover, the contained PL growth factors were implicated in angiogenesis promotion and also in toleration of the inflammatory microenvironment, regulating positively ovarian function. In conclusion, the intraovarian autologous PL injection is considered a safe, effective, and tolerable therapeutic strategy in women with POR or POI. 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引用次数: 0
摘要
卵巢内注射自体血小板裂解液(PL)可被视为卵巢功能恢复的一种潜在治疗策略。特别是对于被诊断为卵巢反应不良(POR)或原发性卵巢功能不全(POI)的妇女,外源性注射自体血小板衍生生长因子可对血清卵泡刺激素(FSH)、黄体生成素(LH)、抗苗勒氏激素(AMH)和雌二醇(E2)的调节产生积极影响。因此,我们对 10 名被确诊为 POR 或 POI 患者(平均年龄为 43±4 岁)进行了上述激素血清水平的评估,这些患者接受了卵巢内注射 PL 的单一疗法。对血清激素水平的监测持续了 3 个月。研究结果清楚地表明,在注射 PL 之前,所有参与者的 FSH 和 LH 水平都升高,E2 和 AMH 水平降低。然而,在跟踪监测的第一个月后,所有激素水平都开始发生变化。此外,40%的参与者通过自然受孕或体外受精(IVF)成功受孕。综上所述,在卵巢内注射自体聚乳酸可改变激素水平,使其达到生理值。此外,所含的聚乳酸生长因子还与促进血管生成和缓解炎症微环境、积极调节卵巢功能有关。总之,对患有 POR 或 POI 的妇女来说,卵巢内注射自体 PL 被认为是一种安全、有效、可耐受的治疗策略。此外,这项研究的结果也非常鼓舞人心,尤其是对于那些有不孕问题、希望生育遗传后代的女性来说。
Rejuvenation of Ovarian Function after Autologous Platelet Lysate Injection: Promising Evidence from Confirmed Cases
Intraovarian injection of autologous Platelet Lysate (PL) can be considered a potential therapeutic strategy for ovarian function rejuvenation. Especially, in women diagnosed with Poor Ovarian Response (POR) or Primary Ovarian Insufficiency (POI), the exogenous administration of the autologous platelet-derived growth factors, influence positively the regulation of the serum Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), and Anti-Mullerian Hormone (AMH) and Estradiol (E2). Therefore, the evaluation of the serum levels of the aforementioned hormones was performed on 10 participants with a mean age of 43 ± 4 years diagnosed with POR or POI, who received intraovarian PL injection monotherapy. The monitoring of the serum hormone levels was performed for 3 months. The results of this study clearly showed that all participants were characterized by elevated levels of FSH and LH and reduced levels of E2 and AMH, prior to the PL injection. However, the levels of all hormones started to change after the 1st month of follow-up monitoring. Moreover, 40% of the participants conceived successfully either by natural way or after in vitro Fertilization (IVF). Considering these, the intraovarian injection of autologous PL exhibited promising evidence regarding the altering of hormone levels at physiological values. Moreover, the contained PL growth factors were implicated in angiogenesis promotion and also in toleration of the inflammatory microenvironment, regulating positively ovarian function. In conclusion, the intraovarian autologous PL injection is considered a safe, effective, and tolerable therapeutic strategy in women with POR or POI. Moreover, the results of this study were very encouraging, especially for the women with infertility issues, who want their genetic offspring.