后部光学相干断层扫描:监测伏立康唑治疗真菌性脉络膜视网膜炎的辅助工具

T. Elhamaky
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引用次数: 0

摘要

:背景:真菌性脉络膜视网膜炎需要早期治疗,以改善视力预后。目的:评估后段光学相干断层扫描(PS-OCT)在治疗真菌性脉络膜视网膜炎中的作用。患者和方法:这是一个病例系列,共有 3 名患者的 5 只眼睛患有真菌性脉络膜视网膜炎。诊断是通过临床和 PS-OCT 确定的。所有患者均接受了全面的眼科检查和 PS-OCT 检测。参与者在 24 小时内接受 6 毫克/千克/12 小时的静脉注射伏立康唑,然后在 4 周内口服伏立康唑 200 毫克,每天两次。结果:随访 6 个月后,BCVA 从 1.15 ± 0.28 降至 0.30 ± 0.09 LogMAR。平均治疗时间为 4.3±1.5 周。随访的 OCT 图像显示脉络膜视网膜病变减小,随访 6 个月时完全消退。随访期间未发现眼部或全身并发症。结论:PS-OCT 可为真菌性脉络膜视网膜炎的全身抗真菌治疗提供一种客观工具,用于评估疾病进展、监测治疗反应,并在我们的研究队列中取得良好的功能和解剖效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Posterior Segment Optical Coherence Tomography: An Adjunctive Tool in Monitoring Voriconazole Treatment of Fungal Chorioretinitis
: Background: Early management of fungal chorioretinitis is necessary to improve the visual prognosis. Purpose : To evaluate the role of posterior segment optical coherence tomography (PS-OCT) in the management of fungal chorioretinitis. Patients and Methods : It is a case series of 5 eyes of 3 participants with fungal chorioretinitis. The diagnosis was established clinically and by PS-OCT. All participants were subjected to a complete ophthalmic examination and PS-OCT. Participants received loading 6mg/kg/12 hours intravenous voriconazole for 24 hours then a cycle of an oral voriconazole 200 mg twice daily for 4 weeks. Results: At 6 months follow-up, BCVA improved from 1.15 ± 0.28 to 0.30 ± 0.09 LogMAR. The mean duration of the treatment was 4.3±1.5 weeks. Follow-up OCT images demonstrated decreased size of chorioretinal lesions and complete resolution at 6-months follow-up. Neither ocular nor systemic complications were reported during the follow-up period. Conclusion : PS-OCT may give an objective tool for systemic antifungal treatments of fungal chorioretinitis assessing the disease progression, monitor therapeutic response, and achieving good functional and anatomical outcomes in our study cohort.
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