分析和评估苯并二氮杂卓新药的开发前景

N. Porseva, F. V. Sobin, A. V. Soloninina, N. A. Pulina, E. R. Kurbatov, O. Dvorskaya
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摘要

导言。使用苯二氮卓类药物治疗各种疾病仍然具有现实意义。苯二氮卓类药物已获得全球大多数监管机构的批准。尽管苯二氮卓类药物存在大量副作用和非医疗用途,但在治疗癫痫长期发作和癫痫状态的急救方面,它们的前景越来越广阔。分析俄罗斯联邦市场上现有的苯二氮杂卓衍生物药物,并评估该方向的发展前景。研究依据的是医疗保健和药品流通领域的规范性法案、俄罗斯和外国作者的出版物,以及使用情境分析、比较分析、结构逻辑分析和内容分析方法进行科学研究的成果。研究的信息基础是在线数据库 "国家药品注册"(grls.minzdrav.gov.ru)、同行评审出版物数据库、PubMed 和 Scopus:结果与讨论。根据以下指标获得了有关苯并二氮杂卓衍生药品范围的数据:国际非专利名称、商品名称、药品、生产国家和企业、剂型。讨论了 "医药主权 "问题。结论。俄罗斯医药市场上的苯二氮卓类药物主要是国产的,而医药物质却存在一定的短缺。在俄罗斯,用于吸入苯并二氮杂卓衍生物的薄膜、透皮膏药和制剂等剂型尚未注册。重要的是,创新的剂型能够提供快速、非侵入性和社会可接受的使用方法,并且患者对治疗的依从性较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis and Evaluation of Prospects for the Development of New Drugs Derived from Benzodiazepines
Introduction. The use of drugs derived from benzodiazepine for the treatment of various diseases continues to be relevant. Benzodiazepines are approved by most regulatory authorities around the world. Despite the large number of side effects and non-medical use, they are becoming more promising in emergency care for prolonged seizures and epileptic status.Aim. To analyze the existing medicines on the market of the Russian Federation based on benzodiazepine derivatives and assess the prospects for development in this direction.Materials and methods. The study was conducted on the basis of regulatory legal acts in the field of healthcare and the circulation of medicines, publications of Russian and foreign authors, the results of scientific research using situational, comparative, structural-logical and content analysis methods. The information base of the study was the online database "State Register of Medicines" (grls.minzdrav.gov.ru), databases of peer-reviewed publications: PubMed and Scopus.Results and discussion. Data were obtained on the range of medicines derived from benzodiazepines according to the following indicators: international nonproprietary names, trade names, medicines, manufacturing countries and enterprises, dosage forms. The problem of "medicinal sovereignty" is discussed. Promising niches have been found for the development of innovative drugs derived from benzodiazepines.Conclusion. It has been established that mainly domestic benzodiazepine-type drugs are represented on the Russian pharmaceutical market, while there is a certain shortage of pharmaceutical substances. In Russia, such dosage forms as films, transdermal plasters and preparations for the inhalation use of benzodiazepine derivatives are not registered. It is important to create innovative dosage forms capable of providing a fast, non-invasive and socially acceptable method of use and a high rate of adherence to treatment by patients.
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