作为给药系统的生物聚合物有组织凝聚相的润湿性和粘附性

IF 0.3 Q4 CRYSTALLOGRAPHY

Liquid Crystals and their Application Pub Date : 2023-12-26 DOI:10.18083/lcappl.2023.4.38

A. I. Galeeva, Nataliya M. Selivanova, Yuriy G. Galyametdinov

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引用次数: 0

摘要

各向同性液晶系统作为定向递送生物物质的载体，主要用于透皮给药及其在皮肤和粘膜上的应用，引起了人们极大的兴趣。研究了乳酸溶液中基于壳聚糖多糖的溶菌酶和凝胶在玻璃基底（基底表面）和半透性聚四氟乙烯膜（表皮角质层模型）表面的润湿和粘附相互作用。研究确定了核黄素药物（维生素 B2）对研究样品表面张力和粘附工作量的影响。研究表明，生物相容性壳聚糖系统可用作药物载体，用于各种生物医学目的，包括透皮给药。

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Wetting and Adhesive Properties of Biopolymer-Based Organized Condensed Phases as Drug Delivery Systems

Lyotropic liquid crystalline systems are of great interest as carriers of biological substances for targeted delivery, mainly for transdermal administration of drugs and their application to the skin and mucous membranes. The wetting and adhesive interactions of lyomesophases and gel based on a chitosan polysaccharide in lactic acid solution on a glass substrate (base surface) and the surface of a semi-permeable polytetrafluoroethylene membrane (model of epidermis horny layer) were studied. The effect of the riboflavin drug (vitamin B2) on the surface tension of studied samples and the amount of adhesion work has been established. It is shown that biocompatible chitosan-containing systems can be used as drug carriers for various biomedical purposes, including transdermal drug delivery.

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来源期刊

Liquid Crystals and their Application CRYSTALLOGRAPHY-

CiteScore

1.30

自引率

40.00%

发文量

期刊介绍： The Journal presents the following main directions of creation/construction, study and application of self-assembled materials: SYNTHESIS, STRUCTURE, PROPERTIES, MEDICINE, BIOLOGY, NANOTECHNOLOGY, SENSORS, PRACTICAL APPLICATION and INFORMATION. The journal is addressed to researchers, lecturers, university students, engineers. The publisher of the journal is the Nanomaterials Research Institute of "Ivanovo State University".