槲寄生软膏对 BALB/c 小鼠 DNCB 诱导的特应性皮炎的抑制作用

IF 2.3 Q3 PHARMACOLOGY & PHARMACY
Chang-Eui Hong, S. Lyu
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引用次数: 0

摘要

特应性皮炎(AD)在全球的发病率越来越高。然而,频繁和长期使用皮质类固醇治疗特应性皮炎有潜在的副作用。韩国槲寄生(Viscum album L. var. coloratum)是一种多年生寄生植物,具有多种生物效应。在本研究中,我们进行了体内研究,以确定韩国槲寄生是否具有抗炎作用,从而在调节 AD 的病理机制中发挥关键作用。我们利用 2,4-二硝基氯苯(DNCB)诱导的 BALB/c 小鼠 AD 样皮损,探讨了 1% 和 2% 韩国槲寄生提取物(KME)软膏的治疗效果。将KME软膏局部涂抹于BALB/c小鼠的背表面,并将其分为四组:正常组、DNCB诱导组、DNCB诱导组(含1% KME软膏)和DNCB诱导组(含2% KME软膏)。用于评估 KME 软膏疗效的每项评估参数都显示,使用 1% KME 软膏后情况有所改善。虽然观察到的效果不如1% KME软膏明显,但使用2% KME软膏后,总体治疗效果也很明显。这些结果表明,韩国槲寄生有可能成为一种治疗注意力缺失症的可行药物。还需要进一步研究以阐明其潜在的作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhibitory Effect of Mistletoe Ointment on DNCB-Induced Atopic Dermatitis in BALB/c Mice
Atopic dermatitis (AD) is increasingly prevalent globally. However, the frequent and prolonged use of corticosteroids, which are commonly employed for AD treatment, carries potential side effects. Korean mistletoe (Viscum album L. var. coloratum), a perennial parasitic plant, has demonstrated various biological effects. In this study, we conducted in vivo investigations to determine whether Korean mistletoe possesses anti-inflammatory effects that play pivotal roles in regulating the pathological mechanisms of AD. BALB/c mice with AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) were utilized to explore the therapeutic effects of 1% and 2% Korean mistletoe extract (KME) ointments. The KME ointment was topically applied to the dorsal surface of the BALB/c mice, and they were categorized into four distinct groups: normal, DNCB-induced, DNCB-induced with 1% KME ointment, and DNCB-induced with 2% KME ointment. Each assessment parameter employed to evaluate the curative impact of the KME ointment displayed improvement with the application of the 1% KME ointment. While the effects observed were less pronounced than those of the 1% KME ointment, the overall therapeutic outcomes were also evident with the utilization of the 2% KME ointment. The results suggest the potential of Korean mistletoe as a viable therapeutic agent for AD. Further investigations are warranted to elucidate the underlying mechanisms of action.
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来源期刊
Scientia Pharmaceutica
Scientia Pharmaceutica Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.60
自引率
4.00%
发文量
67
审稿时长
10 weeks
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