甲状腺激素功能障碍患者的氧化应激和抗氧化剂指标

E. A. Omon, Olawale David Ajayi
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引用次数: 0

摘要

导言和目的。甲状腺激素异常与人体氧化变化有关。本研究旨在评估埃基蒂州甲状腺激素功能障碍患者体内的氧化应激标记物和抗氧化剂状况。材料和方法。本研究共收集了 80 份样本,包括 40 名甲状腺激素功能障碍患者和 40 名表面健康的对照组。用分光光度计测定丙二醛(MDA)、还原型谷胱甘肽(GSH)和过氧化氢酶。结果显示与对照组(4.12±0.63 nmol/mL)相比,受试者的 MDA(4.33±0.84 nmol/mL)显著高于对照组(4.12±0.63 nmol/mL)(P>0.05);受试者的过氧化氢酶(199.与对照组(181.55±16.61 µm/mL)相比,受试者(79.31±10.12 µmol/mL)的过氧化氢酶显著低于对照组(127.21±7.29 µmol/mL)(p<0.05)。结论可以得出结论,甲状腺激素功能障碍患者体内活性氧增加,同时抗氧化系统受损。甲状腺功能减退症和甲状腺功能亢进症会导致氧化/抗氧化平衡失调,进而引发炎症和相关疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
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