与二硫化硫相关的长非编码 RNA 可预测非小细胞肺癌的预后并预示治疗反应

IF 1.4 4区医学 Q4 ONCOLOGY

Oncologie Pub Date : 2024-01-03 DOI:10.1515/oncologie-2023-0384

Huan Liu, Shaohua He, L. Tan, Mingzhen Li, Cheng Chen, Ruiming Tan

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引用次数: 0

摘要

摘要目的二硫化硫是一种新型的细胞死亡形式，在肿瘤细胞中对其进行调节可能是一种很有前景的癌症治疗策略。然而，与二硫化相关的长非编码 RNA（lncRNA）在非小细胞肺癌（NSCLC）中的作用仍未得到充分阐明。本研究旨在探讨二硫化相关lncRNAs（DRLs）的预后意义，并揭示它们与NSCLC免疫微环境的关系。方法通过对基因组数据公共平台（GDC）数据门户获取的NSCLC转录组数据进行共表达分析，确定DRLs。使用最小绝对收缩和选择算子（LASSO）和 Cox 回归分析建立了 DRLs 预后特征（DRLPS）。根据DRLPS的中位二硫化硫评分（DS），将样本分为高DS组和低DS组。然后进行综合分析，以揭示 DRLs 与 NSCLC 微环境之间的关联。其中包括对功能富集、免疫细胞浸润、基因改变和药物敏感性的评估。结果基于六个预后DRLs，即AL606489.1、LINC00857、AP003555.1、AP000695.1、AC113346.1和LINC01615，建立了一个预后特征。Kaplan-Meier生存曲线显示了DRLPS与NSCLC预后的显著相关性。功能富集评估显示，DRLs在NSCLC的免疫调节和新陈代谢中起着关键作用。NSCLC患者中的低DRLPS亚组和高DRLPS亚组在免疫浸润和肿瘤突变负荷方面表现出明显的差异。在 DRLPS 中观察到了预测 NSCLC 治疗中免疫疗法获益和药物敏感性的潜力。结论本研究发现了与二硫化相关的 lncRNAs，并揭示了它们在 NSCLC 中的作用。研究还发现了一种新的预后特征，该特征具有预测 NSCLC 治疗中药物反应的潜力。

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Disulfidptosis-related long non-coding RNAs predict prognosis and indicate therapeutic response in non-small cell lung carcinoma

Abstract Objectives Disulfidptosis is a novel form of cell death, whose modulation in tumor cells may present a promising therapeutic strategy for cancer treatment. However, the role of disulfidptosis-related long non-coding RNAs (lncRNAs) in non-small cell lung carcinoma (NSCLC) remains poorly elucidated. This study aims to investigate the prognostic significance of disulfidptosis-related lncRNAs (DRLs) and reveal their relationship to the immune microenvironment of NSCLC. Methods DRLs were identified through co-expression analysis of NSCLC transcriptomic data obtained from the Genomic Data Commons (GDC) data portal. The DRLs prognostic signature (DRLPS) was established using the least absolute shrinkage and selection operator (LASSO) and Cox regression analyses. Samples were separated into high-DS and low-DS groups based on the median disulfidptosis score (DS) of DRLPS. Integrated analyses were then implemented to unveil the association between DRLs and NSCLC microenvironment. These involved the evaluation of functional enrichments, immune cell infiltrations, genetic alterations, and drug sensitivity. Results A prognostic signature was developed based on six prognostic DRLs, which are AL606489.1, LINC00857, AP003555.1, AP000695.1, AC113346.1, and LINC01615. The Kaplan–Meier survival curves demonstrated the significant association between DRLPS and NSCLC prognosis. The functional enrichment assessment revealed the pivotal involvement of DRLs in immune regulation and metabolism in NSCLC. The low-DS and high-DS subgroups of NSCLC patients exhibited distinct differences in terms of immune infiltration and tumor mutation burden. The potential to predict immunotherapy benefit and drug sensitivity in NSCLC treatments was observed in DRLPS. Conclusions In this study, disulfidptosis-related lncRNAs were identified and their roles in NSCLC were revealed. A novel prognostic signature with the potential to predict drug response in NSCLC treatment was developed.

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来源期刊

Oncologie 医学-肿瘤学

CiteScore

1.30

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Oncologie is aimed to the publication of high quality original research articles, review papers, case report, etc. with an active interest in vivo or vitro study of cancer biology. Study relating to the pathology, diagnosis, and advanced treatment of all types of cancers, as well as research from any of the disciplines related to this field of interest. The journal has English and French bilingual publication.