整合网络药理学：眼科药物发现的新一代方法

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2024-01-05 DOI:10.1016/j.coph.2023.102425

Francesca Lazzara , Federica Conti , Erika Giuffrida , Chiara Maria Eandi , Filippo Drago , Chiara Bianca Maria Platania , Claudio Bucolo

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引用次数: 0

摘要

随着 "全方位 "科学的普及，系统生物学方法可被视为药理学研究的新范例，用于发现新的靶点和/或治疗复杂的多因素疾病。全方位科学的数据可用于生物网络的设计，而生物网络又可通过定量分析来确定新的药理靶点。在这篇综述中，我们将介绍网络药理学的概念，特别是这一创新方法在眼科药理学领域的应用，重点是糖尿病视网膜病变（DR）、老年性黄斑变性（AMD）和青光眼等视网膜疾病。

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Integrating network pharmacology: The next-generation approach in ocular drug discovery

With the spread of the “omics” sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocular pharmacology, with a focus on retinal diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.