催产素增强和神经递质在顺产中的作用:实验评估

IF 1.5 Q3 OBSTETRICS & GYNECOLOGY
Antonio Malvasi , Andrea Ballini , Andrea Tinelli , Bernard Fioretti , Antonella Vimercati , Elko Gliozheni , Giorgio Maria Baldini , Eliano Cascardi , Miriam Dellino , Monica Bonetti , Ettore Cicinelli , Amerigo Vitagliano , Gianluca Raffaello Damiani
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引用次数: 0

摘要

子宫是一个高度神经支配的器官,在分娩过程中,这种神经支配达到最高水平。催产素能纤维在分娩过程中发挥着重要作用,尤其是子宫下段、宫颈和宫底都由运动神经纤维控制。催产素是一种神经激素,作用于子宫平滑肌细胞膜上的受体。在分娩和生产阶段,它的结合会导致肌纤维收缩,从而使宫底发挥中介作用。本研究的目的是调查催产素能纤维在顺产和非顺产患者中的存在情况,研究对象是在第一和第二产程中接受评估的 90 名患者。研究人员收集了子宫肌组织样本,并通过电子显微镜对其进行了评估,以量化研究组和对照组患者神经纤维浓度的差异。实验结果表明,催产素能纤维的浓度在非长期和长期难产之间存在差异。特别是,与非延长时间的顺产相比,延长时间的顺产中催产素纤维的含量较低。催产素的增加似乎对经历长时间难产的患者无效,因为在这组患者中检测到的催产素能纤维的存在发生了变化,导致难产结束。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal

The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone that acts on receptors located on the membrane of the smooth cells of the myometrium. During the stages of labor and delivery, its binding causes myofibers to contract, which enables the fundus of the uterus to act as a mediator. The aim of this study was to investigate the presence of oxytocinergic fibers in prolonged and non-prolonged dystocic delivery in a cohort of 90 patients, evaluated during the first and second stages of labor. Myometrial tissue samples were collected and evaluated by electron microscopy, in order to quantify differences in neurofibers concentrations between the investigated and control cohorts of patients. The authors of this experiment showed that the concentration of oxytocinergic fibers differs between non-prolonged and prolonged dystocic delivery. In particular, in prolonged dystocic delivery, compared to non-prolonged dystocic delivery, there is a lower amount of oxytocin fiber. The increase in oxytocin appeared to be ineffective in patients who experienced prolonged dystocic delivery, since the dystocic labor ended as a result of the altered presence of oxytocinergic fibers detected in this group of patients.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
31
审稿时长
58 days
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