丙酮压迫可提高结直肠癌淋巴结检出率和转移检测率。

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2024-02-01 Epub Date: 2024-01-04 DOI:10.1007/s10585-023-10259-x
Christina Schnoz, Katrin Schmid, Guacimara Ortega Sanchez, Sabina Schacher-Kaufmann, Michel Adamina, Georgios Peros, Dieter Erdin, Peter Karl Bode
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引用次数: 0

摘要

淋巴结状态是结直肠癌最重要的预后因素之一,准确的病理结节分期和淋巴结转移检测对于确定术后治疗至关重要。目前的指南,包括 TNM 分期系统和欧洲肿瘤内科学会(ESMO)指南,都建议至少检查 12 个淋巴结。然而,确定足够数量的淋巴结可能具有挑战性,尤其是在新辅助治疗的情况下,因为新辅助治疗可能会缩小淋巴结的大小。在这项研究中,我们调查了病理科在 2012 年 1 月至 2022 年 12 月期间处理的 384 例结直肠癌切除术,在这些切除术中,常规制备中结肠脂肪组织后检测到的淋巴结数量少于 12 个。通过丙酮压缩,淋巴结收获量明显增加(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.

Acetone compression improves lymph node yield and metastasis detection in colorectal cancer.

Lymph node status is one of the most important prognostic factors in colorectal cancer, and accurate pathological nodal staging and detection of lymph node metastases is crucial for determination of post-operative management. Current guidelines, including the TNM staging system and European Society for Medical Oncology (ESMO) guidelines, recommend examination of at least 12 lymph nodes. However, identification of an adequate number of lymph nodes can be challenging, especially in the setting of neoadjuvant treatment, which may reduce nodal size. In this study, we investigated 384 colorectal cancer resections that were processed at our department of pathology between January 2012 and December 2022, in which the number of detected lymph nodes was less than 12 subsequent to conventional preparation of mesocolic fat tissue. By means of acetone compression, lymph node harvest increased significantly (p < 0.0001), and the intended number of ≥ 12 lymph nodes was achieved in 98% of resection specimens. The number of nodal positive cases increased significantly from n = 95 (24.7%) before versus n = 131 (34.1%) after acetone compression due to additionally identified lymph node metastases (p < 0.001). In 36 patients (9.4%) initially considered as nodal negative, acetone compression led to a staging adjustment to a nodal positive category and thereby drove a recommendation to offer post-operative therapy. In conclusion, acetone compression is a reliable and useful method implementable in routine surgical pathology for the retrieval of lymph nodes in colorectal cancer specimen, allowing for an adequate lymph node sampling and an increase in nodal staging reliability.

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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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