了解影响透明细胞肾细胞癌预后和治疗反应的因素。

IF 8.3 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2024-03-01 Epub Date: 2024-01-05 DOI:10.1097/PAP.0000000000000428

Liwei Jia, Lindsay G Cowell, Payal Kapur

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引用次数: 0

摘要

在这篇综述中，我们重点介绍了肾细胞癌中新出现的形态预后和预测因素，并对其进行了背景分析。我们的重点是透明细胞肾细胞癌（ccRCC），这是最常见的组织学亚型。在过去十年中，我们对ccRCC分子特征的了解有了显著提高。在此，我们将重点介绍这些发现如何为ccRCC患者的预后和治疗决策奠定了新的基础。我们探讨了常见突变、已建立的基因表达特征、瘤内异质性、肉瘤样/横纹肌样形态和 PD-L1 表达的临床相关性，并讨论了它们对预测治疗反应的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Understanding Factors that Influence Prognosis and Response to Therapy in Clear Cell Renal Cell Carcinoma.

In this review, we highlight and contextualize emerging morphologic prognostic and predictive factors in renal cell carcinoma. We focus on clear cell renal cell carcinoma (ccRCC), the most common histologic subtype. Our understanding of the molecular characterization of ccRCC has dramatically improved in the last decade. Herein, we highlight how these discoveries have laid the foundation for new approaches to prognosis and therapeutic decision-making for patients with ccRCC. We explore the clinical relevance of common mutations, established gene expression signatures, intratumoral heterogeneity, sarcomatoid/rhabdoid morphology and PD-L1 expression, and discuss their impact on predicting response to therapy.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.