发育中遗传密码的排序事件

IF 3.6 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

RNA Biology Pub Date : 2024-01-01 Epub Date: 2024-01-03 DOI:10.1080/15476286.2023.2299615

Michael Yarus

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引用次数: 0

摘要

已有的部分遗传密码可以融合进化成完整的标准遗传密码（SGC）。这种代码融合提供了一种 "最少选择 "的途径，很容易产生与 SGC 相似的前体代码。因此，这种 "最少选择 "可以通过最小的变化，也就是快速变化产生 SGC。因此，最佳的代码进化需要延迟的摇摆。早期摇摆编码会减慢代码进化的速度，特别是会减少最有可能的 SGC 前体：近乎完整、准确的代码，它们是代码融合的产物。与此相反的是：在延迟摇摆的情况下，SGC 可以从基于熟练融合编码的截断选择/进化辐射中产生。

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Ordering events in a developing genetic code.

Preexisting partial genetic codes can fuse to evolve towards the complete Standard Genetic Code (SGC). Such code fusion provides a path of 'least selection', readily generating precursor codes that resemble the SGC. Consequently, such least selections produce the SGC via minimal, thus rapid, change. Optimal code evolution therefore requires delayed wobble. Early wobble encoding slows code evolution, very specifically diminishing the most likely SGC precursors: near-complete, accurate codes which are the products of code fusions. In contrast: given delayed wobble, the SGC can emerge from a truncation selection/evolutionary radiation based on proficient fused coding.

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来源期刊

RNA Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： RNA has played a central role in all cellular processes since the beginning of life: decoding the genome, regulating gene expression, mediating molecular interactions, catalyzing chemical reactions. RNA Biology, as a leading journal in the field, provides a platform for presenting and discussing cutting-edge RNA research. RNA Biology brings together a multidisciplinary community of scientists working in the areas of: Transcription and splicing Post-transcriptional regulation of gene expression Non-coding RNAs RNA localization Translation and catalysis by RNA Structural biology Bioinformatics RNA in disease and therapy