与细菌脂多糖有关的聚糖的最新化学合成和免疫学评估

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-01-03 DOI:10.1016/j.cbpa.2023.102424

Chunjun Qin , Guangzong Tian , Jing Hu , Xiaopeng Zou , Jian Yin

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引用次数: 0

摘要

细菌脂多糖（LPS）的O型抗原和核心寡糖通常结构独特，免疫活性高，已成为开发抗菌疫苗的诱人靶标。结构明确、纯度高的寡糖可用于确定碳水化合物抗原的保护性表位，这对设计有效的疫苗非常重要。本文总结了与细菌 LPS 的 O 抗原和核心寡糖相关的聚糖的化学合成和免疫学评估的最新进展。

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Recent chemical synthesis and immunological evaluation of glycans related to bacterial lipopolysaccharides

O-Antigens and core oligosaccharides from bacterial lipopolysaccharides (LPS) are often structurally unique and immunologically active, have become attractive targets in the development of antibacterial vaccines. Structurally well-defined and pure oligosaccharides can be used in identifying protective epitopes of the carbohydrate antigens, which is important for the design of an effective vaccine. Here, the recent progress on chemical synthesis and immunological evaluation of glycans related to O-antigens and core oligosaccharides from bacterial LPS are summarized.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.