MMP-9基因多态性对癌症风险的影响：最新系统综述和荟萃分析。

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2024-01-03 DOI:10.1080/15257770.2023.2299710

Zhihai Teng, Song Wang, Hao Yuan, Hu Wang, Jingdong Li, Xueliang Chang, Yanping Zhang, Zhenwei Han, Yaxuan Wang

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引用次数: 0

摘要

全面阐述 MMP-9 基因多态性（rs3918242）与癌症易感性的关系。在 PubMed、Medline、Google Scholar 和 Web of Science 上对 2022 年 5 月 27 日之前发表的符合条件的候选基因研究进行了文献检索。在亚组和敏感性分析中寻找潜在的异质性来源。此外，还对发表偏倚进行了估计。总体而言，共有 37 篇文章对 rs3918242 基因多态性进行了研究，涉及 7616 例病例和 8165 例对照。我们的荟萃分析表明，MMP-9 rs3918242可能与乳腺癌和胃癌的易感性有关，也可能降低肺癌的风险。

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MMP-9 gene polymorphisms on cancer risk: an updated systematic review and meta-analysis.

To provide a comprehensive account of the association of MMP-9 gene polymorphisms (rs3918242) with susceptibility to cancer. A literature search for eligible candidate gene studies published before May 27, 2022 was conducted in PubMed, Medline, Google Scholar and Web of Science. Potential sources of heterogeneity were sought out across subgroups and sensitivity analysis. Publication bias were also estimated. Overall, a total of 37 articles with 7616 cases and 8165 controls for rs3918242 gene polymorphisms were enrolled. Our meta-analysis suggests that MMP-9 rs3918242 might be associated with breast cancer and gastric cancer susceptibility, and perhaps reduce the risk of lung cancer.

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来源期刊

Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

6 months

期刊介绍： Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.