通过 O-GlcNAcylation 调节突触传递

IF 3.3 3区医学 Q2 NEUROSCIENCES

Molecular Brain Pub Date : 2024-01-02 DOI:10.1186/s13041-023-01072-4

Seunghyo Han, Jun-Nyeong Kim, Chan Ho Park, Jin-Seok Byun, Do-Yeon Kim, Hyoung-Gon Ko

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引用次数: 0

摘要

O-GlcNAcylation 是一种翻译后修饰，N-乙酰葡糖胺（O-GlcNAc）在两种酶的作用下从丝氨酸/苏氨酸位置上连接或脱离：O-GlcNAc转移酶和O-GlcNAcase。除了在糖尿病和癌症中的作用外，最近的药理学和遗传学研究发现，O-GlcNAcylation 还参与神经元功能，特别是突触传递。全面改变 O-GlcNAc 水平不会影响基础突触传递，但对突触可塑性的影响尚不清楚。尽管被 O-GlcNAcylated 的突触蛋白正逐渐被发现，但关于 O-GlcNAcylated 的突触蛋白如何调节突触传递的机制，目前仅有关于 CREB、突触素和 AMPAR 的 GluA2 亚基的报道。未来能够操纵单个突触蛋白中 O-GlcNAcylation 的研究应能揭示 O-GlcNAcylated 突触蛋白作为突触传递调节因子的隐秘方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modulation of synaptic transmission through O-GlcNAcylation

O-GlcNAcylation is a posttranslational modification where N-acetylglucosamine (O-GlcNAc) is attached and detached from a serine/threonine position by two enzymes: O-GlcNAc transferase and O-GlcNAcase. In addition to roles in diabetes and cancer, recent pharmacological and genetic studies have revealed that O-GlcNAcylation is involved in neuronal function, specifically synaptic transmission. Global alteration of the O-GlcNAc level does not affect basal synaptic transmission while the effect on synaptic plasticity is unclear. Although synaptic proteins that are O-GlcNAcylated are gradually being discovered, the mechanism of how O-GlcNAcylated synaptic protein modulate synaptic transmission has only been reported on CREB, synapsin, and GluA2 subunit of AMPAR. Future research enabling the manipulation of O-GlcNAcylation in individual synaptic proteins should reveal hidden aspects of O-GlcNAcylated synaptic proteins as modulators of synaptic transmission.

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来源期刊

Molecular Brain NEUROSCIENCES-

CiteScore

7.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.