关于维生素 D 对神经精神狼疮的影响，我们了解多少？

IF 2 4区医学 Q3 RHEUMATOLOGY

Advances in Rheumatology Pub Date : 2024-01-02 DOI:10.1186/s42358-023-00344-w

Thaís Evelyn Karnopp, Vinicius da Silva Freitas, Andressa Leite Di Domenico, Gustavo Flores Chapacais, Natália Garcia dos Santos, Eduarda Correa Freitas, Andrese Aline Gasparin, Odirlei André Monticielo

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引用次数: 0

摘要

系统性红斑狼疮（SLE）是一种可影响多个器官和系统的自身免疫性疾病。中枢和/或外周神经系统会出现并发症，即神经精神性狼疮（NPSLE）。研究表明，系统性红斑狼疮或非系统性红斑狼疮的表现与维生素 D 缺乏有关。研究表明，维生素D不足可导致非系统性红斑狼疮患者出现认知障碍和脑灌注不足。在这篇综述文章中，我们将讨论在非系统性红斑狼疮患者或动物模型中，维生素D补充或血清维生素D水平与神经精神表现相关的主要特征。

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What is known about the effects of vitamin D in neuropsychiatric lupus?

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.

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来源期刊

Advances in Rheumatology Medicine-Rheumatology

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

53 weeks

期刊介绍： Formerly named Revista Brasileira de Reumatologia, the journal is celebrating its 60th year of publication. Advances in Rheumatology is an international, open access journal publishing pre-clinical, translational and clinical studies on all aspects of paediatric and adult rheumatic diseases, including degenerative, inflammatory and autoimmune conditions. The journal is the official publication of the Brazilian Society of Rheumatology and welcomes original research (including systematic reviews and meta-analyses), literature reviews, guidelines and letters arising from published material.