补体与老年性黄斑变性的关系及其发病机制

IF 1.8 4区医学 Q3 OPHTHALMOLOGY

Journal of Ophthalmology Pub Date : 2024-01-02 DOI:10.1155/2024/6416773

Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou

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引用次数: 0

摘要

老年黄斑变性是一种视网膜疾病，会导致 65 岁以上的人永久丧失中心视力。其发病机制可能与线粒体功能障碍、炎症、细胞凋亡、自噬、补体、肠道菌群和脂质紊乱有关。此外，患者的基因、年龄、性别、心血管疾病、不健康的饮食和生活习惯也可能是该病的危险因素。补体蛋白广泛分布于血清和组织液中。21 世纪初，人们发现补体级联与老年性黄斑变性之间存在联系。然而，人们对补体因子对老年性黄斑变性发病机制的影响知之甚少。本文回顾了与老年性黄斑变性相关的因素、各因素与补体之间的关系、相关功能和变异，并为治疗这种疾病提供了新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis

Age-related macular degeneration is a retinal disease that causes permanent loss of central vision in people over the age of 65. Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. In addition, the patient’s genes, age, gender, cardiovascular disease, unhealthy diet, and living habits may also be risk factors for this disease. Complement proteins are widely distributed in serum and tissue fluid. In the early 21st century, a connection was found between the complement cascade and age-related macular degeneration. However, little is known about the effect of complement factors on the pathogenesis of age-related macular degeneration. This article reviews the factors associated with age-related macular degeneration, the relationship between each factor and complement, the related functions, and variants and provides new ideas for the treatment of this disease.

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来源期刊

Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY

CiteScore

4.30

自引率

5.30%

发文量

194

审稿时长

6-12 weeks

期刊介绍： Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.