结直肠癌微环境中瘤内微生物群的动态相互作用

IF 9.7 4区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

VIEW Pub Date : 2023-12-29 DOI:10.1002/viw.20230100

Yuanyuan Wu, Pingping Wang, Xinyu Zhao, Ti Liu, Bo Situ, Lei Zheng

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引用次数: 0

摘要

结直肠癌（CRC）是一种复杂的恶性肿瘤，不仅受到癌细胞的影响，还受到肿瘤微环境（TME）的影响。在肿瘤微环境中，新出现的证据强调了被称为瘤内微生物群的各种微生物实体的存在和功能作用。这些微生物群的分布具有显著的异质性，并与肿瘤细胞发生动态的相互作用，形成了一个独特的生态系统。某些细菌菌株会明显影响 CRC 的 TME，从而影响肿瘤的特征和进展。这篇综述总结了瘤内微生物群在 CRC TME 中错综复杂的作用，强调了它们在疾病发展和进程中的重要性，并讨论了该领域的机遇和挑战。

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Dynamic interplay of intratumoral microbiota within the colorectal cancer microenvironment

Colorectal cancer (CRC) is a complex malignancy, influenced not only by cancer cells but also by the tumor microenvironment (TME). Within the TME, emerging evidence highlights the presence and functional roles of diverse microbial entities, referred to as intratumoral microbiota. The distribution of these microbiota exhibits significant heterogeneity and engages in dynamic interactions with tumor cells, forming a unique ecosystem. Certain bacterial strains distinctly influence the TME of CRC, affecting the characteristics and progression of the tumor. This review summarizes the intricate roles of intratumoral microbiota within CRC's TME, emphasizing their importance in the disease's development and progression, and discuss the opportunities and challenges in the field.

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来源期刊

VIEW Multiple-

CiteScore

12.60

自引率

2.30%

发文量

审稿时长

10 weeks

期刊介绍： View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.