Stephanie A Ruderman, Lydia N Drumright, Joseph A C Delaney, Allison R Webel, Annette L Fitzpatrick, Bridget M Whitney, Robin M Nance, Andrew W Hahn, Jimmy Ma, L Sarah Mixson, Sherif Eltonsy, Amanda L Willig, Kenneth H Mayer, Sonia Napravnik, Meredith Greene, Mary McCaul, Edward Cachay, Stephen B Kritchevsky, Steven N Austad, Alan Landay, Michael S Saag, Mari M Kitahata, Bryan Lau, Catherine Lesko, Geetanjali Chander, Heidi M Crane, Michelle C Odden
{"title":"在一项纵向临床队列研究中，评估艾滋病毒感染者的虚弱状态和减少饮酒的 \"病态戒酒假说\"。","authors":"Stephanie A Ruderman, Lydia N Drumright, Joseph A C Delaney, Allison R Webel, Annette L Fitzpatrick, Bridget M Whitney, Robin M Nance, Andrew W Hahn, Jimmy Ma, L Sarah Mixson, Sherif Eltonsy, Amanda L Willig, Kenneth H Mayer, Sonia Napravnik, Meredith Greene, Mary McCaul, Edward Cachay, Stephen B Kritchevsky, Steven N Austad, Alan Landay, Michael S Saag, Mari M Kitahata, Bryan Lau, Catherine Lesko, Geetanjali Chander, Heidi M Crane, Michelle C Odden","doi":"10.1097/JNC.0000000000000441","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>\"Sick quitting,\" a phenomenon describing reductions in alcohol consumption following poor health, may explain observations that alcohol appears protective for frailty risk. We examined associations between frailty and reductions in drinking frequency among people with HIV (PWH). At six Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites between January 2012 and August 2021, we assessed whether frailty, measured through validated modified frailty phenotype, precedes reductions in drinking frequency. We associated time-updated frailty with quitting and reducing frequency of any drinking and heavy episodic drinking (HED), adjusted for demographic and clinical characteristics in Cox models. Among 5,654 PWH reporting drinking, 60% reported >monthly drinking and 18% reported ≥monthly HED. Over an average of 5.4 years, frail PWH had greater probabilities of quitting (HR: 1.56, 95% confidence interval [95% CI] [1.13-2.15]) and reducing (HR: 1.35, 95% CI [1.13-1.62]) drinking frequency, as well as reducing HED frequency (HR: 1.58, 95% CI [1.20-2.09]) versus robust PWH. Sick quitting likely confounds the association between alcohol use and frailty risk, requiring investigation for control.</p>","PeriodicalId":50263,"journal":{"name":"Janac-Journal of the Association of Nurses in Aids Care","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.\",\"authors\":\"Stephanie A Ruderman, Lydia N Drumright, Joseph A C Delaney, Allison R Webel, Annette L Fitzpatrick, Bridget M Whitney, Robin M Nance, Andrew W Hahn, Jimmy Ma, L Sarah Mixson, Sherif Eltonsy, Amanda L Willig, Kenneth H Mayer, Sonia Napravnik, Meredith Greene, Mary McCaul, Edward Cachay, Stephen B Kritchevsky, Steven N Austad, Alan Landay, Michael S Saag, Mari M Kitahata, Bryan Lau, Catherine Lesko, Geetanjali Chander, Heidi M Crane, Michelle C Odden\",\"doi\":\"10.1097/JNC.0000000000000441\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>\\\"Sick quitting,\\\" a phenomenon describing reductions in alcohol consumption following poor health, may explain observations that alcohol appears protective for frailty risk. 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Evaluating the Sick Quitting Hypothesis for Frailty Status and Reducing Alcohol Use Among People With HIV in a Longitudinal Clinical Cohort Study.
Abstract: "Sick quitting," a phenomenon describing reductions in alcohol consumption following poor health, may explain observations that alcohol appears protective for frailty risk. We examined associations between frailty and reductions in drinking frequency among people with HIV (PWH). At six Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites between January 2012 and August 2021, we assessed whether frailty, measured through validated modified frailty phenotype, precedes reductions in drinking frequency. We associated time-updated frailty with quitting and reducing frequency of any drinking and heavy episodic drinking (HED), adjusted for demographic and clinical characteristics in Cox models. Among 5,654 PWH reporting drinking, 60% reported >monthly drinking and 18% reported ≥monthly HED. Over an average of 5.4 years, frail PWH had greater probabilities of quitting (HR: 1.56, 95% confidence interval [95% CI] [1.13-2.15]) and reducing (HR: 1.35, 95% CI [1.13-1.62]) drinking frequency, as well as reducing HED frequency (HR: 1.58, 95% CI [1.20-2.09]) versus robust PWH. Sick quitting likely confounds the association between alcohol use and frailty risk, requiring investigation for control.
期刊介绍：
The Journal of the Association of Nurses in AIDS Care (JANAC) is a peer-reviewed, international nursing journal that covers the full spectrum of the global HIV epidemic, focusing on prevention, evidence-based care management, interprofessional clinical care, research, advocacy, policy, education, social determinants of health, epidemiology, and program development. JANAC functions according to the highest standards of ethical publishing practices and offers innovative publication options, including Open Access and prepublication article posting, where the journal can post articles before they are published with an issue.
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