从腺苷受体激动剂、拮抗剂或其异位调节剂中寻找治疗心血管疾病的新药剂的问题和前景。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2023-12-01 DOI:10.18097/PBMC20236906353

V N Perfilova, E A Muzyko, A S Taran, A A Shevchenko, L V Naumenko

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引用次数: 0

摘要

A1 腺苷受体（A1AR）广泛分布于人体内，并介导多种不同的效应。它们大量存在于心血管系统中，控制着血管生成、血管张力、心率和传导。这使得心血管系统 A1AR 成为治疗心血管疾病（CVD）的诱人靶点。这篇综述总结了有关 A1AR 结构和功能的文献数据，分析了它们在心肌肥厚、缺血再灌注损伤、各种类型的心律紊乱、慢性心力衰竭和动脉高血压的形成过程中的参与作用。研究特别关注了 A1AR 的一些异构调节剂作为治疗心血管疾病的潜在药物的作用。

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Problems and prospects for finding new pharmacological agents among adenosine receptor agonists, antagonists, or their allosteric modulators for the treatment of cardiovascular diseases.

A1-adenosine receptors (A1AR) are widely distributed in the human body and mediate many different effects. They are abundantly present in the cardiovascular system, where they control angiogenesis, vascular tone, heart rate, and conduction. This makes the cardiovascular system A1AR an attractive target for the treatment of cardiovascular diseases (CVD). The review summarizes the literature data on the structure and functioning of A1AR, and analyzes their involvement in the formation of myocardial hypertrophy, ischemia-reperfusion damage, various types of heart rhythm disorders, chronic heart failure, and arterial hypertension. Special attention is paid to the role of some allosteric regulators of A1AR as potential agents for the CVD treatment.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).