垂体性脑瘫评分,走向标准化决策:一项描述性研究。

IF 3.3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Pituitary Pub Date : 2024-02-01 Epub Date: 2023-12-27 DOI:10.1007/s11102-023-01372-x
Henri Salle, Mathilde Cane, Maxime Rocher, Emilie Auditeau, Marie-Pierre Teissier, Gerald Raverot, Laurence Salle
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引用次数: 0

摘要

垂体性脑瘫(PA)是垂体腺瘤的一种罕见且危及生命的并发症,需要紧急应用糖皮质激素。关于最佳手术方法还存在争议,而垂体性脑瘫评分(PAS)有助于做出决策。我们的回顾性研究(2003-2022 年)评估了 PA 患者组(手术与非手术)中的变量,应用 PAS 确定了手术决策的重要阈值。此外,我们还旨在比较两组患者的眼科和内分泌缺陷率,并确定任何相关变量。我们观察到 PAS 存在差异,平均值为 1.7 ± 1.7(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pituitary apoplexy score, toward standardized decision-making: a descriptive study.

Pituitary apoplexy score, toward standardized decision-making: a descriptive study.

Pituitary apoplexy (PA), a rare and life-threatening complication of pituitary adenomas, prompts urgent glucocorticoid administration. The optimal surgical approach is debated, and the Pituitary Apoplexy Score (PAS) aids decision-making. Our retrospective study (2003-2022) assesses variables in PA patient groups (surgical vs. non-surgical), applying PAS to establish a significant threshold for surgical decisions. Additionally, we aim to compare the rates of ophthalmological and endocrine deficit between both groups and identify any associated variables. PAS discrepancies were observed, with averages of 1.7 ± 1.7 (p < 0.0001) for conservative and 3.9 ± 1.7 (p < 0.0001) for surgical groups, confirmed by multivariate analysis (p = 0.009). A PAS threshold of 5, showing over 80% positive predictive value, was established. Patients with low prolactin levels (< 5 ng/ml) had higher corticotropic deficiency prevalence at 3-month and 1-year follow-ups (p = 0.017 and 0.027). Our study supports PAS as a valuable PA management tool, suggesting potential variable adjustments. Multicenter studies are crucial due to PA's low incidence.

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来源期刊
Pituitary
Pituitary 医学-内分泌学与代谢
CiteScore
7.10
自引率
7.90%
发文量
90
审稿时长
6 months
期刊介绍: Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease. The journal considers: Biology of Pituitary Tumors Mechanisms of Pituitary Hormone Secretion Regulation of Pituitary Function Prospective Clinical Studies of Pituitary Disease Critical Basic and Clinical Reviews Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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