酶法和化学酶法合成 N-和 O-聚糖的最新进展

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2023-12-22 DOI:10.1016/j.cbpa.2023.102417

Zhi-Fei Hu , Kan Zhong , Hongzhi Cao

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引用次数: 0

摘要

糖基化是蛋白质最常见的翻译后修饰之一，在调节蛋白质的生物功能方面起着至关重要的作用。生物研究和生物医学应用急需高效、多用途的方法来合成均一、定义明确的 N-和 O-糖。尽管 N-和 O-聚糖结构复杂，但近年来在合成 N-和 O-聚糖方面取得了巨大进展。本综述讨论了酶法和化学酶法合成 N-和 O-聚糖的一些最新进展。

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Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans

Glycosylation is one of the most common post-translational modifications of proteins, which plays essential roles in regulating the biological functions of proteins. Efficient and versatile methods for the synthesis of homogeneous and well-defined N- and O-glycans remain an urgent need for biological studies and biomedical applications. Despite their structural complexity, tremendous progress has been made in the synthesis of N- and O-glycans in recent years. This review discusses some recent advances in the enzymatic and chemoenzymatic synthesis of N- and O-glycans.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.