杆菌属代表基因组中抗菌药耐药性基因库的比较生物信息学分析

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Bulletin of Russian State Medical University Pub Date : 2023-12-01 DOI:10.24075/brsmu.2023.047

TA Kulshan, IO Bugaeva, EF Soboleva, MS Allyanova, DA Popov, IG Shvidenko

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引用次数: 0

摘要

目前，细菌传染源的多重耐药性对全球公共卫生构成了严重威胁。下列棒状杆菌菌株对感染（包括医院获得性感染）具有特别重要的意义：amycolatum棒状杆菌、urealyticum棒状杆菌、striatum棒状杆菌、jeikeium棒状杆菌：C.amycolatum、C.urealyticum、C.striatum、C.jeikeium、C.aurimucosum、C.genitalium，它们对广谱抗菌药物具有耐药性。该研究旨在对已公布的部分棒状杆菌属成员基因组中的抗菌药耐药基因库进行生物信息学分析。研究人员评估了从 NCBI GenBank 获取的 22 个科里纳菌分离株的全基因组核苷酸序列数据。利用 PATRIC 在线资源对全基因组序列进行了生物信息学分析，以便在指定基因组中搜索抗菌药耐药性基因。结果发现，所提供的基因组包含 25 个抗菌药物耐药性基因的不同组合。在一些棒状杆菌菌株中发现了 GyrA（第 87、88 和 91 位）的氨基酸替换，通过这种替换可实现对喹诺酮/氟喹诺酮类药物的耐药性。

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Comparative bioinformatics analysis of antimicrobial resistance gene pool in the genomes of representatives of genus Corynebacterium

Currently, multidrug resistance of bacterial infectious agents poses a serious threat to the global public health. The following Corynebacterium strains are of special importance for infections, including hospital-acquired ones: C. amycolatum, C. urealyticum, C. striatum, C. jeikeium, C. aurimucosum, C. genitalium that are resistant to the broad spectrum of antimicrobial drugs. The study was aimed to conduct bioinformatics analysis of the pool of antimicrobial resistance genes in the published genomes of some members of the genus Corynebacterium. The data on the whole genome nucleotide sequences of 22 Corynebacterium isolates readily available from NCBI GenBank were assessed. Bioinformatics analysis of the whole genome sequences conducted in order to search for antimicrobial resistance genes in the specified genomes was performed using the PATRIC online resource. It was found that the genomes provided comprised various combinations of 25 antimicrobial drug resistance genes. Amino acid substitutions in GyrA (positions 87, 88 and 91) were revealed in some Corynebacterium strains, through which quinolone/fluoroquinolone resistance could be realized.

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来源期刊

Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.