一例因脱发而引发的肌无力症

IF 1.1 Q4 ALLERGY
Naoki Sasaki MD, Yu Sawada MD, PhD
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引用次数: 0

摘要

我们介绍了一例在斑秃之后发生的重症肌无力,并对有关斑秃和重症肌无力合并症的文献进行了评估。一名 41 岁的男性在 4 个月前发现自己的头皮脱发,随着脱发的发展,他出现了双上眼皮下垂和复视。体格检查和实验室检查发现他合并患有重症肌无力和斑秃。住院后,他连续 7 天服用泼尼松龙 10 毫克/天和他克莫司 3 毫克/天,复视和眼睑下垂的情况有所改善。甲基强的松龙治疗后,斑秃患者的脱发情况有所改善,但秃头部位没有扩大。根据文献回顾,包括本病例在内,共有 29 例脱发合并肌萎缩症的病例。其中,7 例在脱发后出现肌无力。脱发后出现重症肌无力的平均时间为 16.6 个月。有四例患者合并有其他自身免疫性疾病,如白癜风、扁平苔藓、皮肤红斑狼疮和丘疹性荨麻疹,这表明这些患者体内存在Th1-显著的免疫状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A case of myasthenia gravis following alopecia areata

A case of myasthenia gravis following alopecia areata

We present a case of myasthenia gravis that occurred after alopecia areata and evaluate the literature on the comorbidity of alopecia and myasthenia gravis. A 41-year-old male noticed hair loss on his scalp 4 months ago, and his hair loss progressed with drooping of both upper eyelids and diplopia. Physical and laboratory examination identified the comorbidity of myasthenia gravis and alopecia areata. Prednisolone 10 mg/day and tacrolimus 3 mg/day were administered for 7 days following hospitalization, which served to improve diplopia and ptosis. Following methylprednisolone therapy, hair loss in alopecia areata improved without the enlargement of bald areas. Based on the literature review, a total of 29 cases with alopecia and myasthenia gravis including our case have been reported. Among them, seven cases of myasthenia gravis developed after alopecia. The average time for the onset of myasthenia gravis after alopecia was 16.6 months. Four cases showed other autoimmune disease comorbidity, such as vitiligo, lichen planus, cutaneous lupus erythematosus, and pemphigus foliaceus, suggesting the involvement of Th1-significant immunological states in these patients.

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来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
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