钦奈非政府组织收容所中无家可归者的结核病感染率和患病率

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-12-11 DOI:10.1177/09720634231214883

Chandrakumar Dolla, Bhaskaran Dhanaraj, Chandrasekaran Padmapriyadarsini, Muniyandi Malaisamy, Thiruvengadam Kannan, Pradeep Aravindan Menon, Rajendran Krishnan, Kumaravel P, Vijayalakshmi R, Devaki D, S. Tripathy

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引用次数: 0

摘要

肺结核潜伏感染（LTBI）是结核分枝杆菌感染后的一个不活跃阶段，它会重新活化为肺结核（PTB）。本研究旨在估算居住在印度钦奈大都会区 13 家由非政府组织运营的收容所中的无家可归者中的 LTBI 患病率。这项横断面调查于 2018 年 1 月至 4 月进行。使用结核菌素皮肤试验（TST）和疾病涂片及培养检查对所有 15 岁及以上的收容者进行了 PTB 感染筛查。在总共 1 068 名登记人员中，1 016 人接受了 PTB 疾病筛查，818 人接受了 LTBI 筛查。其中，2 人检测出 PTB，275 人 TST 呈阳性。研究人员进行了单变量和多变量分析，以找出与迟发性肺结核相关的因素。结果发现，LTBI 与男性、40 岁以上和胸部 X 光结核病灶明显相关。这项研究结果突出表明，结核病的发病率很低，三分之一的无家可归者感染了结核病。我们的发现表明，有必要采取预防干预措施，以消除这一重点人群中的结核病。

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Prevalence of Tuberculosis Infection and Disease Among Homeless Persons Staying in NGO Shelters in Chennai

Latent tuberculosis infection (LTBI) is a inactive stage after being infected with Mycobacterium tuberculosis and it reactivates into pulmonary tuberculosis (PTB). This study was to estimate the prevalence of LTBI in homeless persons staying in 13 shelters run by NGOs in Chennai metro city, India. A cross-sectional survey was conducted from January to April 2018. All inmates aged 15 years and above were screened for PTB infection using tuberculin skin test (TST) and disease smear and culture examinations. Out of a total of 1,068 registered, 1,016 persons were screened for PTB disease and 818 persons for LTBI. Among them, PTB was detected in two persons and TST was positive in 275 persons. Univariate and multivariate analyses were performed to find out the factors associated with LTBI. It was found that LTBI is significantly associated with male gender, aged more than 40 years and with chest X-ray TB lesions. This study finding highlights that low prevalence of TB disease and one third of homeless persons infected with tuberculosis. Our finding suggests that there is a need for prevention interventions to eliminate TB in this key population.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.