将小儿肾病综合征视为荚膜细胞病变

P. A. S. Vaz de Castro, Thomas Fujihara Ide, Fernando Crespo Torres, A. C. Simões e Silva
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引用次数: 0

摘要

肾病综合征(NS)是一种以蛋白尿、低蛋白血症和水肿为特征的复杂临床实体。在这篇综述中,我们提出了将肾病综合征视为荚膜细胞病的观点,强调了了解荚膜细胞在该病症发展过程中的作用的重要性。我们讨论了 NS 的各种病因,包括先天性肾脏疾病、原发性肾脏疾病以及由全身性疾病引起的继发性肾脏疾病。我们还深入探讨了荚膜细胞损伤的内在机制,这种损伤在 NS 的发病过程中起着至关重要的作用。通过将 NS 视为一种荚膜细胞病变,我们提出了诊断和治疗这种疾病的潜在意义,包括使用荚膜细胞特异性生物标记物和靶向疗法。我们的综述全面概述了 NS 及其内在机制,强调了采用多学科方法诊断和治疗这种疾病的重要性。为了更好地了解荚膜细胞损伤与 NS 发生之间复杂的相互作用,最终改善患者的预后,进一步的研究是必不可少的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The View of Pediatric Nephrotic Syndrome as a Podocytopathy
Nephrotic syndrome (NS) is a complex clinical entity characterized by proteinuria, hypoalbuminemia, and edema. In this review, we propose the view of NS as a podocytopathy, highlighting the importance of understanding the role of podocytes in the development of this condition. We discuss the various etiologies of NS, ranging from congenital to primary renal diseases, as well as secondary forms due to systemic diseases. We also delve into the mechanisms underlying podocyte injury, which plays a crucial role in the development of NS. By viewing NS as a podocytopathy, we suggest potential implications for the diagnosis and treatment of this condition, including the use of podocyte-specific biomarkers and targeted therapies. Our review provides a comprehensive overview of NS and its underlying mechanisms, emphasizing the importance of a multidisciplinary approach to the diagnosis and management of this condition. Further research is essential to better understand the complex interplay between podocyte injury and the development of NS, with the ultimate goal of improving patient outcomes.
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