{"title":"TAFI 现象及其临床意义","authors":"I. N. Bokarev, A. P. Melnikov, S. I. Burykh","doi":"10.30629/0023-2149-2023-101-11-521-524","DOIUrl":null,"url":null,"abstract":"Thrombin activatable fi brinolysis inhibitor (TAFI) is one of the key proteins of fi brinolysis and infl ammation systems. Based on literature data, information is presented on the biological eff ects of TAFI, the mechanisms of its activation, gene polymorphism that determines the duration of its action and activity. Nosological forms are listed, where TAFI is important in the pathogenesis of the development of diseases, its role in experimental and laboratory studies, and the possibility of pharmacological infl uence on the activity of this protein.","PeriodicalId":10439,"journal":{"name":"Clinical Medicine (Russian Journal)","volume":"46 12","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TAFI phenomenon and its clinical significance\",\"authors\":\"I. N. Bokarev, A. P. Melnikov, S. I. Burykh\",\"doi\":\"10.30629/0023-2149-2023-101-11-521-524\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thrombin activatable fi brinolysis inhibitor (TAFI) is one of the key proteins of fi brinolysis and infl ammation systems. Based on literature data, information is presented on the biological eff ects of TAFI, the mechanisms of its activation, gene polymorphism that determines the duration of its action and activity. Nosological forms are listed, where TAFI is important in the pathogenesis of the development of diseases, its role in experimental and laboratory studies, and the possibility of pharmacological infl uence on the activity of this protein.\",\"PeriodicalId\":10439,\"journal\":{\"name\":\"Clinical Medicine (Russian Journal)\",\"volume\":\"46 12\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-12-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Medicine (Russian Journal)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30629/0023-2149-2023-101-11-521-524\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine (Russian Journal)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30629/0023-2149-2023-101-11-521-524","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Thrombin activatable fi brinolysis inhibitor (TAFI) is one of the key proteins of fi brinolysis and infl ammation systems. Based on literature data, information is presented on the biological eff ects of TAFI, the mechanisms of its activation, gene polymorphism that determines the duration of its action and activity. Nosological forms are listed, where TAFI is important in the pathogenesis of the development of diseases, its role in experimental and laboratory studies, and the possibility of pharmacological infl uence on the activity of this protein.
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