芬太尼在癌症疼痛治疗中的应用：避免草率判断并辨别其潜在益处

Q2 Pharmacology, Toxicology and Pharmaceutics

Drugs in Context Pub Date : 2023-12-14 DOI:10.7573/dic.2023-10-2

Arturo Cuomo

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引用次数: 0

摘要

癌痛是治疗过程中的一大难题，需要快速起效才能控制。尤其是，突破性癌痛（BTcP）应通过稳定剂量的短效口服阿片类药物得到充分控制。芬太尼是一种人工合成的高选择性阿片类药物，具有许多有利的化学特性，包括高亲脂性和独特的药代动力学特性。它被推荐用于各种情况下的疼痛治疗，包括急性疼痛、慢性疼痛和 BTcP。迄今为止，芬太尼的各种设计配方均可实现非侵入性给药；其中，舌下芬太尼已被证明可用于治疗 BTcP 和改善癌症患者的生活质量。鉴于芬太尼仍是治疗癌症疼痛的重要工具，本综述将介绍使用芬太尼治疗 BTcP 的最新情况，并考虑其安全性。

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Fentanyl in cancer pain management: avoiding hasty judgments and discerning its potential benefits

Cancer pain is an important challenge in treatment and requires a rapid onset of action for its control. In particular, breakthrough cancer pain (BTcP) should be adequately controlled with a stable dose of a short-acting oral opioid. Fentanyl is a synthetic, highly selective opioid with many advantageous chemical properties, including high lipophilicity and distinct pharmacokinetic properties. It is recommended for pain management in a variety of settings, including acute pain, chronic pain and BTcP. To date, its variously designed formulations allow non-invasive administration; amongst others, sublingual fentanyl has proven useful in the management of BTcP and in improving the quality of life of patients with cancer. This review provides an update on the management of BTcP with fentanyl, with consideration of safety, as it remains an important tool in the treatment of cancer pain.

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来源期刊

Drugs in Context Medicine-Medicine (all)

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： Covers all phases of original research: laboratory, animal and human/clinical studies, health economics and outcomes research, and postmarketing studies. Original research that shows positive or negative results are welcomed. Invited review articles may cover single-drug reviews, drug class reviews, latest advances in drug therapy, therapeutic-area reviews, place-in-therapy reviews, new pathways and classes of drugs. In addition, systematic reviews and meta-analyses are welcomed and may be published as original research if performed per accepted guidelines. Editorials of key topics and issues in drugs and therapeutics are welcomed. The Editor-in-Chief will also consider manuscripts of interest in areas such as technologies that support diagnosis, assessment and treatment. EQUATOR Network reporting guidelines should be followed for each article type. GPP3 Guidelines should be followed for any industry-sponsored manuscripts. Other Editorial sections may include Editorial, Case Report, Conference Report, Letter-to-the-Editor, Educational Section.